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Zonegran(zonisamide)
Zonegran, Zonisade (zonisamide) is a small molecule pharmaceutical. Zonisamide was first approved as Zonegran on 2000-03-27. It is used to treat epilepsy and partial epilepsies in the USA. It has been approved in Europe to treat epilepsy and partial epilepsies. It is known to target carbonic anhydrase 7, carbonic anhydrase 12, and carbonic anhydrase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Zonegran, Zonisade (generic drugs available since 2005-12-22)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Zonisamide
Tradename
Company
Number
Date
Products
ZONISADEAzurityN-214273 RX2022-07-15
1 products, RLD, RS
ZONEGRANConcordia LaboratoriesN-020789 RX2000-03-27
2 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
zonegranNew Drug Application2020-04-09
zonisadeNew Drug Application2022-07-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
epilepsyEFO_0000474D004827G40.9
partial epilepsiesEFO_0004263D004828
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Zonisamide, Zonisade, Azurity
114784562038-08-18U-3458
115293332038-08-18DP
ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AX: Other antiepileptics in atc
N03AX15: Zonisamide
HCPCS
No data
Clinical
Clinical Trials
70 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.9169319
AlcoholismD000437EFO_0003829F10.1631111
ObesityD009765EFO_0001073E66.931116
SeizuresD012640G40.42114
Parkinson diseaseD010300EFO_0002508G2011113
Migraine disordersD008881EFO_0003821G431113
Partial epilepsiesD004828EFO_000426322
Bipolar disorderD001714EFO_0000289F30.9112
Parkinsonian disordersD020734HP_000130011
DyskinesiasD020820G2411
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20112
Psychotic disordersD011618F20.81112
Smoking cessationD016540EFO_000431922
Weight gainD015430HP_000432411
Complex partial epilepsyD017029EFO_100087711
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Noise-induced hearing lossD006317EFO_1001254133
Post-traumatic stress disordersD013313EFO_0001358F43.122
Essential tremorD020329EFO_0003108G25.0112
Tobacco use disorderD014029F17111
Cocaine-related disordersD019970F14111
Obstructive sleep apneaD020181EFO_0003918G47.3311
Sleep apnea syndromesD012891EFO_0003877G47.311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients66
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZONISAMIDE
INNzonisamide
Description
Zonisamide is a 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position. It has a role as an anticonvulsant, an antioxidant, a central nervous system drug, a protective agent and a T-type calcium channel blocker. It is a member of 1,2-benzoxazoles and a sulfonamide.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)Cc1noc2ccccc12
Identifiers
PDB
CAS-ID68291-97-4
RxCUI39998
ChEMBL IDCHEMBL750
ChEBI ID10127
PubChem CID5734
DrugBankDB00909
UNII ID459384H98V (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA7
CA7
CA12
CA12
CA1
CA1
Organism
Homo sapiens
Gene name
CA7
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 7
Protein synonyms
CA-VII, Carbonate dehydratase VII, Carbonic anhydrase VII, carbonic dehydratase VII
Uniprot ID
Mouse ortholog
Car7 (12354)
carbonic anhydrase 7 (Q9ERQ8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,887 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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78,892 adverse events reported
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