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Ziprasidone
Geodon (ziprasidone) is a small molecule pharmaceutical. Ziprasidone was first approved as Geodon on 2001-02-05. It is used to treat schizophrenia, schizophrenia spectrum and other psychotic disorders, and tourette syndrome in the USA. The pharmaceutical is active against D(2) dopamine receptor, 5-hydroxytryptamine receptor 2A, and 5-hydroxytryptamine receptor 2C. In addition, it is known to target 5-hydroxytryptamine receptor 1E, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 7, histamine H1 receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1D, and sodium-dependent noradrenaline transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
mental disordersD001523
Trade Name
FDA
EMA
Geodon (generic drugs available since 2012-03-02)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ziprasidone hydrochloride
Tradename
Company
Number
Date
Products
GEODONViatrisN-020825 RX2001-02-05
4 products, RLD
Show 1 discontinued
Ziprasidone mesylate
Tradename
Company
Number
Date
Products
GEODONViatrisN-020919 RX2002-06-21
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
geodonNew Drug Application2022-02-23
ziprasidone hydrochlorideANDA2023-05-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
schizophreniaEFO_0000692D012559F20
schizophrenia spectrum and other psychotic disorders—D019967—
tourette syndromeEFO_0004895D005879F95.2
Agency Specific
FDA
EMA
Expiration
Code
ZIPRASIDONE HYDROCHLORIDE, GEODON, VIATRIS
2025-01-28M-232
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AE: Indole derivatives, antipsychotic
— N05AE04: Ziprasidone
HCPCS
Code
Description
J3486
Injection, ziprasidone mesylate, 10 mg
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Insulin resistanceD007333EFO_0002614————11
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9————11
Pulmonary heart diseaseD011660I27.81————11
Eosinophilic esophagitisD057765EFO_0004232K20.0————11
Colorectal neoplasmsD015179————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZIPRASIDONE
INNziprasidone
Description
Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. It has a role as a psychotropic drug, a histamine antagonist, a muscarinic antagonist, a serotonergic antagonist, a dopaminergic antagonist and an antipsychotic agent. It is a member of piperazines, an organochlorine compound, a member of indolones and a 1,2-benzisothiazole.
Classification
Small molecule
Drug classantipsychotic with binding activity on sertonin (5-HT2A) and dopamine (D2) receptors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
Identifiers
PDB—
CAS-ID146939-27-7
RxCUI115698
ChEMBL IDCHEMBL708
ChEBI ID10119
PubChem CID60854
DrugBankDB00246
UNII ID6UKA5VEJ6X (ChemIDplus, GSRS)
Target
Agency Approved
DRD2
DRD2
HTR2A
HTR2A
HTR2C
HTR2C
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Alternate
HTR1E
HTR1E
SLC6A4
SLC6A4
HTR1B
HTR1B
HTR7
HTR7
HRH1
HRH1
HTR1A
HTR1A
HTR1D
HTR1D
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
HTR1E
Gene synonyms
NCBI Gene ID
3354
Protein name
5-hydroxytryptamine receptor 1E
Protein synonyms
5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, Serotonin receptor 1E
Uniprot ID
Q9P1Y1
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
Geodon - Pfizer
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,329 documents
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Safety
Black-box Warning
Black-box warning for: Geodon, Ziprasidone hydrochloride
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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