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Zafirlukast
Accolate (zafirlukast) is a small molecule pharmaceutical. Zafirlukast was first approved as Accolate on 1996-09-26. It is used to treat asthma in the USA. The pharmaceutical is active against cysteinyl leukotriene receptor 1. In addition, it is known to target cysteinyl leukotriene receptor 2, bifunctional epoxide hydrolase 2, and peroxisome proliferator-activated receptor gamma.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
immune system diseasesD007154
Trade Name
FDA
EMA
Accolate (generic drugs available since 2010-11-18)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Zafirlukast
Tradename
Company
Number
Date
Products
ACCOLATEStrides Pharma GlobalN-020547 RX1996-09-26
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
accolateNew Drug Application2022-12-13
zafirlukastNew Drug Application2023-04-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
asthmaEFO_0000270D001249J45
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DC: Leukotriene receptor antagonists for obstructive airway diseases
— R03DC01: Zafirlukast
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Mucopolysaccharidosis viiD016538E76.29————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZAFIRLUKAST
INNzafirlukast
Description
Zafirlukast is a member of indoles, a carbamate ester and a N-sulfonylcarboxamide. It has a role as an anti-asthmatic agent and a leukotriene antagonist.
Classification
Small molecule
Drug classantiasthmatics/antiallergics (not acting primarily as antihistamines): leukotriene receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
Identifiers
PDB6RZ5
CAS-ID107753-78-6
RxCUI114970
ChEMBL IDCHEMBL603
ChEBI ID10100
PubChem CID5717
DrugBankDB00549
UNII IDXZ629S5L50 (ChemIDplus, GSRS)
Target
Agency Approved
CYSLTR1
CYSLTR1
Organism
Homo sapiens
Gene name
CYSLTR1
Gene synonyms
CYSLT1
NCBI Gene ID
10800
Protein name
cysteinyl leukotriene receptor 1
Protein synonyms
Cysteinyl leukotriene D4 receptor, G-protein coupled receptor HG55, HMTMF81, LTD4 receptor
Uniprot ID
Q9Y271
Mouse ortholog
Cysltr1 (58861)
cysteinyl leukotriene receptor 1 (Q9JK47)
Alternate
CYSLTR2
CYSLTR2
EPHX2
EPHX2
PPARG
PPARG
Organism
Homo sapiens
Gene name
CYSLTR2
Gene synonyms
CYSLT2, CYSLT2R
NCBI Gene ID
57105
Protein name
cysteinyl leukotriene receptor 2
Protein synonyms
cysteinyl leukotriene CysLT2 receptor, G-protein coupled receptor GPCR21, G-protein coupled receptor HG57, hGPCR21, HPN321
Uniprot ID
Q9NS75
Mouse ortholog
Cysltr2 (70086)
cysteinyl leukotriene receptor 2 (Q920A1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,277 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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27 adverse events reported
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