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Erivedge(vismodegib)
Erivedge (vismodegib) is a small molecule pharmaceutical. Vismodegib was first approved as Erivedge on 2012-01-30. It is used to treat skin neoplasms in the USA. It has been approved in Europe to treat basal cell carcinoma. The pharmaceutical is active against smoothened homolog.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Erivedge
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vismodegib
Tradename
Company
Number
Date
Products
ERIVEDGEGenentechN-203388 RX2012-01-30
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
erivedgeNew Drug Application2020-08-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
skin neoplasmsEFO_0004198D012878C44
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Vismodegib, Erivedge, Genentech
92789612028-12-15U-1825
78883642028-11-11DS, DP
97901832025-09-02U-3109
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01X: Other antineoplastic agents in atc
L01XJ: Hedgehog pathway inhibitors
L01XJ01: Vismodegib
HCPCS
No data
Clinical
Clinical Trials
81 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Basal cell neoplasmsD0182952132421
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8047111
Pancreatic neoplasmsD010190EFO_0003860C25548
Breast neoplasmsD001943EFO_0003869C50235
MedulloblastomaD008527245
Prostatic neoplasmsD011471C61324
Multiple myelomaD009101C90.0224
Ovarian neoplasmsD010051EFO_0003893C5644
Skin neoplasmsD012878EFO_0004198C441214
Basal cell nevus syndromeD001478EFO_0004136314
Colorectal neoplasmsD01517933
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
Primary myelofibrosisD055728D47.422
Myelodysplastic syndromesD009190D4611
Hematologic neoplasmsD01933711
Castration-resistant prostatic neoplasmsD06412911
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.011
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_000034011
Myelomonocytic leukemia chronicD015477C93.111
AnemiaD000740EFO_0004272D64.911
Hodgkin diseaseD006689C8111
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVISMODEGIB
INNvismodegib
Description
Vismodegib is a benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma. It has a role as an antineoplastic agent, a SMO receptor antagonist, a Hedgehog signaling pathway inhibitor and a teratogenic agent. It is a sulfone, a member of benzamides, a member of pyridines and a member of monochlorobenzenes.
Classification
Small molecule
Drug classhedgehog signaling inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1
Identifiers
PDB5L7I
CAS-ID879085-55-9
RxCUI1242987
ChEMBL IDCHEMBL473417
ChEBI ID66903
PubChem CID24776445
DrugBankDB08828
UNII ID25X868M3DS (ChemIDplus, GSRS)
Target
Agency Approved
SMO
SMO
Organism
Homo sapiens
Gene name
SMO
Gene synonyms
SMOH
NCBI Gene ID
Protein name
smoothened homolog
Protein synonyms
frizzled family member 11, Protein Gx, seven transmembrane helix receptor, smoothened, frizzled family receptor, smoothened, seven transmembrane spanning receptor
Uniprot ID
Mouse ortholog
Smo (319757)
smoothened homolog (P56726)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Erivedge - Roche
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,387 documents
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Safety
Black-box Warning
Black-box warning for: Erivedge
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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