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Vidarabine
Vira-a (vidarabine) is a small molecule pharmaceutical. Vidarabine was first approved as Vira-a on 1982-01-01. It is used to treat chickenpox, herpes simplex, herpes zoster, herpetic keratitis, and infectious keratoconjunctivitis in the USA. The pharmaceutical is active against adenosine deaminase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
eye diseasesD005128
skin and connective tissue diseasesD017437
animal diseasesD000820
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vidarabine
Tradename
Company
Number
Date
Products
VIRA-AParkedale PharmaceuticalsN-050486 DISCN1982-01-01
1 products
VIRA-AParkedale PharmaceuticalsN-050523 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
chickenpoxEFO_0007204D002644B01
herpes simplex—D006561B00
herpes zosterEFO_0006510D006562B02
herpetic keratitisEFO_0007308D016849—
infectious keratoconjunctivitis—D007639—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB03: Vidarabine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD06: Vidarabine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVIDARABINE
INNvidarabine
Description
Adenine arabinoside is a purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. It has a role as an antineoplastic agent, a bacterial metabolite and a nucleoside antibiotic. It is a purine nucleoside and a beta-D-arabinoside. It is functionally related to an adenine.
Classification
Small molecule
Drug classantineoplastics (arabinofuranosyl derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
Identifiers
PDB—
CAS-ID5536-17-4
RxCUI11194
ChEMBL IDCHEMBL1090
ChEBI ID45327
PubChem CID21704
DrugBankDB00194
UNII ID3XQD2MEW34 (ChemIDplus, GSRS)
Target
Agency Approved
ADA
ADA
Organism
Homo sapiens
Gene name
ADA
Gene synonyms
ADA1
NCBI Gene ID
100
Protein name
adenosine deaminase
Protein synonyms
Adenosine aminohydrolase
Uniprot ID
Q6LA59
Mouse ortholog
Ada (11486)
adenosine deaminase (P03958)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 2,008 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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