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Chantix, Champix(varenicline)
Champix, Tyrvaya (varenicline) is a small molecule pharmaceutical. Varenicline was first approved as Chantix on 2006-05-10. It has been approved in Europe to treat tobacco use cessation. The pharmaceutical is active against neuronal acetylcholine receptor subunit alpha-4. In addition, it is known to target neuronal acetylcholine receptor subunit alpha-3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
behavior and behavior mechanismsD001520
Trade Name
FDA
EMA
Tyrvaya (generic drugs available since 2021-08-11, discontinued: Chantix)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Varenicline tartrate
Tradename
Company
Number
Date
Products
TYRVAYAOyster Point PharmaN-213978 RX2021-10-15
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
chantixNew Drug Application2021-07-12
tyrvayaNew Drug Application2021-10-20
vareniclineANDA2023-06-16
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
VARENICLINE TARTRATE, TYRVAYA, OYSTER POINT PHARMA
2024-10-15NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Varenicline Tartrate, Tyrvaya, Oyster Point Pharma
95046442035-10-19U-1900
95046452035-10-19DP
95329442035-10-19U-1900
95972842035-10-19U-1900
104563962035-10-19DPU-1900
112245982035-10-19U-1900
ATC Codes
N: Nervous system drugs
N07: Other nervous system drugs in atc
N07B: Drugs used in addictive disorders
N07BA: Drugs used in nicotine dependence
N07BA03: Varenicline
HCPCS
No data
Clinical
Clinical Trials
309 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Smoking cessationD016540EFO_00043191318273819109
Tobacco use disorderD014029F1762121202181
SmokingD012907EFO_0003768F17412812838
Cigarette smokingD0000738655625218
AlcoholismD000437EFO_0003829F10.121122116
SchizophreniaD012559EFO_0000692F2051915
Dry eye syndromesD015352H04.12144312
Substance-related disordersD019966EFO_0003890F13332210
Tobacco use cessationD02034022429
HivD006678O98.72428
Show 27 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tobacco useD064424Z72.0134
Lung neoplasmsD008175C34.9021114
Hiv infectionsD015658EFO_0000764B201213
ObesityD009765EFO_0001073E66.9212
Harm reductionD040261111
Disease progressionD01845011
HabitsD006184111
Friedreich ataxiaD005621Orphanet_95G11.11111
Smoking reductionD00007426411
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F14516
Second primary neoplasmsD01660911
Weight gainD015430HP_0004324111
Machado-joseph diseaseD017827EFO_000413511
Post-traumatic stress disordersD013313EFO_0001358F43.111
Alzheimer diseaseD000544EFO_0000249F0311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients44
Head and neck neoplasmsD006258213
Squamous cell carcinoma of head and neckD000077195112
PharmacokineticsD01059922
CognitionD003071EFO_000392511
Nasopharyngeal neoplasmsD00930311
Chronic painD059350HP_001253211
Biological availabilityD00168211
Amphetamine-related disordersD019969EFO_0004701F1511
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8022
Cardiovascular diseasesD002318EFO_0000319I9822
Depressive disorderD003866EFO_1002014F32.A22
SleepD012890GO_003043111
Non-small-cell lung carcinomaD00228911
Health behaviorD01543811
PeriodontitisD010518EFO_0000649K05.311
Myocardial infarctionD009203EFO_0000612I2111
AnxietyD001007EFO_0005230F41.111
Prediabetic stateD011236EFO_1001121R73.0311
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVARENICLINE
INNvarenicline
Description
Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation and for the treatment of dry eye disease. It is a nicotinic receptor partial agonist and a cholinergic agonist. When activated, this receptor releases dopamine in the nucleus accumbens, the brain's reward center, thereby reducing cravings and withdrawal symptoms associated with smoking cessation.
Classification
Small molecule
Drug classnicotinic acetylcholine receptor partial agonists/agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
c1cnc2cc3c(cc2n1)C1CNCC3C1
Identifiers
PDB5AIN
CAS-ID249296-44-4
RxCUI591622
ChEMBL IDCHEMBL1396
ChEBI ID
PubChem CID170361
DrugBankDB01273
UNII IDW6HS99O8ZO (ChemIDplus, GSRS)
Target
Agency Approved
CHRNA4
CHRNA4
Organism
Homo sapiens
Gene name
CHRNA4
Gene synonyms
NACRA4
NCBI Gene ID
Protein name
neuronal acetylcholine receptor subunit alpha-4
Protein synonyms
cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Uniprot ID
Mouse ortholog
Chrna4 (11438)
neuronal acetylcholine receptor subunit alpha-4 (Q9ET51)
Alternate
CHRNA3
CHRNA3
Organism
Homo sapiens
Gene name
CHRNA3
Gene synonyms
NACHRA3
NCBI Gene ID
Protein name
neuronal acetylcholine receptor subunit alpha-3
Protein synonyms
cholinergic receptor, nicotinic alpha 3, cholinergic receptor, nicotinic, alpha 3 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 3, neuronal nicotinic acetylcholine receptor, alpha3 subunit
Uniprot ID
Mouse ortholog
Chrna3 (110834)
neuronal acetylcholine receptor subunit alpha-3 (Q8R4G9)
Variants
Clinical Variant
No data
Financial
Chantix - Pfizer
$
£
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Tyrvaya - Oyster Point Pharma
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,059 documents
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Safety
Black-box Warning
Black-box warning for: Chantix
Adverse Events
Top Adverse Reactions
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59,178 adverse events reported
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