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Bextra, Valdyn (previously kudeq)(valdecoxib)
Bextra, Kudeq, Valdyn (valdecoxib) is a small molecule pharmaceutical. Valdecoxib was first approved as Bextra on 2001-11-16. It is used to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. It has been approved in Europe to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target carbonic anhydrase 12 and carbonic anhydrase 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Valdecoxib
Tradename
Company
Number
Date
Products
BEXTRAG.D. SearleN-021341 DISCN2001-11-16
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dysmenorrheaHP_0100607D004412N94.6
osteoarthritisEFO_0002506D010003M15-M19
rheumatoid arthritisEFO_0000685D001172M06.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AH: Coxibs
— M01AH03: Valdecoxib
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tardive dyskinesiaD000071057G24.011542—11
TorticollisD014103HP_0000473F45.8———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Huntington diseaseD006816G10——2——2
SchizophreniaD012559EFO_0000692F20——2——2
Cerebral palsyD002547G80——1——1
DyskinesiasD020820G24——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tourette syndromeD005879EFO_0004895F95.217———8
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVALDECOXIB
INNvaldecoxib
Description
Valdecoxib is a member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke. It has a role as a non-steroidal anti-inflammatory drug, a cyclooxygenase 2 inhibitor, a non-narcotic analgesic, an antirheumatic drug and an antipyretic. It is a member of isoxazoles and a sulfonamide.
Classification
Small molecule
Drug classcyclooxygenase-2 inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1
Identifiers
PDB2AW1
CAS-ID181695-72-7
RxCUI278567
ChEMBL IDCHEMBL865
ChEBI ID63634
PubChem CID119607
DrugBankDB00580
UNII ID2919279Q3W (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
5743
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Q16876
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
CA12
CA12
CA2
CA2
Organism
Homo sapiens
Gene name
CA12
Gene synonyms
NCBI Gene ID
771
Protein name
carbonic anhydrase 12
Protein synonyms
CA-XII, Carbonate dehydratase XII, Carbonic anhydrase XII, carbonic dehydratase, Tumor antigen HOM-RCC-3.1.3
Uniprot ID
Q9BWG2
Mouse ortholog
Car12 (76459)
carbonic anhydrase 12 (Q8CI85)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,860 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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17,228 adverse events reported
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