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Troleandomycin
Tao (troleandomycin) is a small molecule pharmaceutical. Troleandomycin was first approved as Tao on 1982-01-01. It is used to treat asthma, campylobacter infections, chlamydia infections, gonorrhea, and legionnaires' disease amongst others in the USA. It is known to target cytochrome P450 3A4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Troleandomycin
Tradename
Company
Number
Date
Products
TAOMylanN-050332 DISCN1982-01-01
1 products
TAOMylanN-050336 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
asthmaEFO_0000270D001249J45
campylobacter infectionsEFO_0007190D002169—
chlamydia infectionsEFO_0007205D002690A74.9
gonorrheaDOID_7551D006069A54
legionnaires' diseaseEFO_0007343D007877A48.1
mycoplasma infections—D009175—
staphylococcal infections—D013203A49.01
streptococcal infectionsEFO_1001476D013290—
syphilisEFO_0007504D013587A53.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01F: Macrolides, lincosamides and streptogramins
— J01FA: Macrolides
— J01FA08: Troleandomycin
HCPCS
No data
Clinical
Clinical Trials
149 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61112176437
InfertilityD007246EFO_000054514717937
Female infertilityD007247EFO_0008560N972223310
EndometriosisD004715EFO_0001065N80113239
Polycystic ovary syndromeD011085EFO_0000660E28.2111327
Fertilization in vitroD005307——1517
Precocious pubertyD011629E22.8——61—7
Intracytoplasmic sperm injectionsD020554———4—4
Ovarian hyperstimulation syndromeD016471——13—4
Primary ovarian insufficiencyD016649EFO_0004266E28.311—1—2
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50—56——11
AdenocarcinomaD000230122——4
LymphomaD008223C85.9—23——3
Male breast neoplasmsD018567111——2
SarcomaD012509—12——2
OsteosarcomaD012516—12——2
Ewing sarcomaD012512EFO_0000173—12——2
Bone neoplasmsD001859EFO_0003820D16——1——1
Fertility preservationD059247—11——1
Neoadjuvant therapyD020360—11——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_000054411———1
LeiomyomaD007889HP_0000131D2511———1
Ectopic pregnancyD011271O0011———1
SalpingitisD012488N70.9111———1
Triple negative breast neoplasmsD064726—1———1
Drug-related side effects and adverse reactionsD064420T88.7—1———1
Salivary gland neoplasmsD012468EFO_0003826D11—1———1
Female urogenital diseasesD052776—1———1
Hiv infectionsD015658EFO_0000764B20—1———1
Systemic lupus erythematosusD008180EFO_0002690M32—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
AdenomyosisD062788EFO_1001757N80.01————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.1————22
Embryo implantationD010064————11
Hodgkin diseaseD006689C81————11
Pregnancy rateD018873————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTROLEANDOMYCIN
INNtroleandomycin
Description
Troleandomycin is a semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug. It has a role as an EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor and a xenobiotic. It is a macrolide antibiotic, a polyketide, a monosaccharide derivative, an epoxide, an acetate ester and a semisynthetic derivative. It is functionally related to an oleandomycin.
Classification
Small molecule
Drug classantibiotics (Streptomyces strain)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1C[C@H](O[C@@H]2[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@]3(CO3)C[C@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3OC(C)=O)[C@H]2C)O[C@@H](C)[C@@H]1OC(C)=O
Identifiers
PDB—
CAS-ID2751-09-9
RxCUI10864
ChEMBL IDCHEMBL564085
ChEBI ID45735
PubChem CID202225
DrugBankDB01361
UNII IDC4DZ64560D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
CYP3A4
Gene synonyms
CYP3A3
NCBI Gene ID
1576
Protein name
cytochrome P450 3A4
Protein synonyms
1,4-cineole 2-exo-monooxygenase, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Albendazole sulfoxidase, Cholesterol 25-hydroxylase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, Cytochrome P450-PCN1, glucocorticoid-inducible P450, Nifedipine oxidase, P450-III, steroid inducible, Quinine 3-monooxygenase, taurochenodeoxycholate 6-alpha-hydroxylase
Uniprot ID
P08684
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 642 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,606 adverse events reported
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