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Trimipramine
Surmontil (trimipramine) is a small molecule pharmaceutical. Trimipramine was first approved as Surmontil on 1982-01-01. It is used to treat depressive disorder and psychotic affective disorders in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter, sodium-dependent noradrenaline transporter, and sodium-dependent dopamine transporter. In addition, it is known to target G protein-activated inward rectifier potassium channel 2, muscarinic acetylcholine receptor M2, potassium voltage-gated channel subfamily H member 1, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trimipramine maleate
Tradename
Company
Number
Date
Products
SURMONTILOdyssey PharmaceuticalsN-016792 DISCN1982-01-01
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
trimipramine maleateANDA2023-06-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
psychotic affective disordersD000341F39
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N06: Psychoanaleptics
N06A: Antidepressants
N06AA: Non-selective monoamine reuptake inhibitors
N06AA06: Trimipramine
HCPCS
No data
Clinical
Clinical Trials
169 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2036144530
Pneumocystis pneumoniaD011020EFO_0007448B5914123220
Urinary tract infectionsD014552EFO_0003103N39.0357419
InfectionsD007239EFO_0000544122318
MalariaD008288EFO_0001068B54718
Methicillin-resistant staphylococcus aureusD05562421115
PneumoniaD011014EFO_0003106J181415
TuberculosisD014376EFO_0000774A15-A192214
HivD006678O98.7123
BacteriuriaD001437R82.711113
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A4951118
AbscessD000038EFO_0003030246
SepsisD018805A41.9134
Staphylococcal infectionsD013203A49.01234
MycosesD009181B35-B49112
PneumocystisD01101022
Idiopathic pulmonary fibrosisD054990J84.11222
Multiple myelomaD009101C90.0112
Vesico-ureteral refluxD014718EFO_0007536N13.722
OsteomyelitisD010019EFO_0003102M86112
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.91314
Cystic fibrosisD003550EFO_0000390E8433
SinusitisD012852EFO_0007486J32112
Type 1 diabetes mellitusD003922EFO_0001359E10112
Chronic kidney failureD007676EFO_0003884N18.6112
NeoplasmsD009369C80212
Staphylococcus aureusD013211NCBITaxon_1280112
LeukemiaD007938C95122
Kidney diseasesD007674EFO_0003086N08222
Kidney transplantationD016030222
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Congenital microtiaD065817Q16.011
Oxidative stressD018384EFO_100190511
Lacrimal duct obstructionD00776711
Short bowel syndromeD01277811
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
BronchitisD001991J4033
HypospadiasD007021EFO_0004209Q5422
DeliriumD003693R41.011
Ulcerative colitisD003093EFO_0000729K5111
Non-hodgkin lymphomaD008228C85.911
Pregnancy complicationsD01124811
UrolithiasisD052878N20-N2311
Bacterial skin diseasesD01719211
CellulitisD002481EFO_0003035L03.9011
Diabetic footD017719EFO_100145911
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRIMIPRAMINE
INNtrimipramine
Description
Trimipramine is a dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant. It has a role as an antidepressant, an environmental contaminant and a xenobiotic. It is a dibenzoazepine and a tertiary amino compound. It is functionally related to an imipramine.
Classification
Small molecule
Drug classantidepressants (imipramine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(CN(C)C)CN1c2ccccc2CCc2ccccc21
Identifiers
PDB
CAS-ID739-71-9
RxCUI10834
ChEMBL IDCHEMBL644
ChEBI ID9738
PubChem CID5584
DrugBankDB00726
UNII ID6S082C9NDT (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
KCNJ6
KCNJ6
CHRM2
CHRM2
KCNH1
KCNH1
KCNJ5
KCNJ5
Organism
Homo sapiens
Gene name
KCNJ6
Gene synonyms
GIRK2, KATP2, KCNJ7
NCBI Gene ID
Protein name
G protein-activated inward rectifier potassium channel 2
Protein synonyms
BIR1, Inward rectifier K(+) channel Kir3.2, inward rectifier potassium channel KIR3.2, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6, potassium channel, inwardly rectifying subfamily J, member 6, potassium voltage-gated channel subfamily J member 6
Uniprot ID
Mouse ortholog
Kcnj6 (16522)
G protein-activated inward rectifier potassium channel 2 (P48542)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,410 documents
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Safety
Black-box Warning
Black-box warning for: Trimipramine maleate
Adverse Events
Top Adverse Reactions
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35,556 adverse events reported
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