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Tramadol
Conzip, Qdolo, Seglentis, Ultracet (tramadol) is a small molecule pharmaceutical. Tramadol was first approved as Ultram on 1995-03-03. It is used to treat pain in the USA.
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Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Conzip, Qdolo (generic drugs available since 2002-06-19, discontinued: Rybix, Ryzolt, Ultram)
Combinations
Seglentis (generic drugs available since 2002-06-19, discontinued: Ultracet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
+
Tramadol hydrochloride
Tradename
Company
Number
Date
Products
ULTRACETJohnson & JohnsonN-021123 DISCN2001-08-15
1 products, RLD
Hide discontinued
Celecoxib
+
Tramadol hydrochloride
Tradename
Company
Number
Date
Products
SEGLENTISKowaN-213426 RX2021-10-15
1 products, RLD, RS
Tramadol hydrochloride
Tradename
Company
Number
Date
Products
QDOLOAthena NeurosciencesN-214044 RX2020-09-01
1 products, RLD, RS
CONZIPCipher PharmaceuticalsN-022370 RX2010-05-07
3 products, RLD
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
conzipNew Drug Application2022-01-20
qdoloNew Drug Application2020-09-14
ryzoltNew Drug Application2010-11-19
seglentisNew Drug Application2021-10-25
tramadol hydrochlorideANDA2023-06-13
ultracetNew Drug Application2022-01-31
ultramicrosize griseofulvinANDA2023-04-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
Expiration
Code
CELECOXIB / TRAMADOL HYDROCHLORIDE, SEGLENTIS, KOWA PHARMS
2024-10-15NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Tramadol Hydrochloride, Qdolo, Athena
111034522040-09-01DPU-3197
Celecoxib / Tramadol Hydrochloride, Seglentis, Kowa Pharms
88467442031-06-03DP
85981522030-04-19DS, DP
90124402030-04-19DS, DP
102386682030-04-19DS, DPU-3244
102452762030-04-19DS, DP
105489092030-04-19U-3244
114784882030-04-19U-3244
Tramadol Hydrochloride, Ryzolt, Purdue Pharma
79889982023-10-27DP
ATC Codes
N: Nervous system drugs
N02: Analgesics
N02A: Opioid analgesics
N02AJ: Opioids in combination with non-opioid analgesics
N02AJ13: Tramadol and paracetamol
N02AJ14: Tramadol and dexketoprofen
N02AJ15: Tramadol and other non-opioid analgesics
N02AJ16: Tramadol and celecoxib
N02AX: Other opioids in atc
N02AX02: Tramadol
HCPCS
No data
Clinical
Clinical Trials
274 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52951416448
Postoperative painD010149G89.1812181536
Healthy volunteers/patients133117
Acute painD059787R52444315
OsteoarthritisD010003EFO_0002506M15-M192216112
Low back painD017116HP_0003419M54.51253112
HysteroscopyD015907415
NeuralgiaD009437EFO_000943012115
PulpitisD011671EFO_1001139K04.011225
AnalgesiaD0006981124
Show 57 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic painD059350HP_001253229212
Opioid-related disordersD009293EFO_0005611F113415
Knee osteoarthritisD020370EFO_0004616M17145
Pain managementD05940811315
Breast neoplasmsD001943EFO_0003869C502113
Procedural painD000073818213
Substance withdrawal syndromeD013375EFO_0005800111
PancreatitisD010195EFO_0000278K8511
Muscle weaknessD018908HP_0001324111
Abdominal painD015746R10.911
Show 6 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Squamous cell carcinoma of head and neckD00007719511
PruritusD011537HP_0000989L2911
NauseaD009325HP_0002018R11.011
VertigoD014717H81.3911
Laron syndromeD046150Orphanet_633E34.32111
Major depressive disorderD003865EFO_0003761F2211
MelanomaD008545111
Eye neoplasmsD005134EFO_0003824C69.9111
Wounds and injuriesD014947T14.811
Shoulder fracturesD012784S42.911
Show 3 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD01059933
Therapeutic equivalencyD01381022
AgingD000375GO_0007568R41.8111
Biological availabilityD00168211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nerve blockD00940744
CholecystectomyD00276322
Intervertebral disc degenerationD055959HP_000841911
Sleep deprivationD012892F51.1211
BurnsD002056T30.011
Pituitary neoplasmsD01091111
NephrectomyD00939211
AnxietyD001007EFO_0005230F41.111
Intervertebral disc displacementD007405EFO_100180011
Periapical abscessD010482EFO_100120211
Show 15 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRAMADOL
INNtramadol
Description
(R,R)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, a serotonin uptake inhibitor and a metabolite. It is a conjugate base of a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol.
Classification
Small molecule
Drug classanalgesics (mixed opiate receptor agonists/antagonists)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cccc(C2(O)CCCCC2CN(C)C)c1
Identifiers
PDB
CAS-ID2914-77-4
RxCUI10689
ChEMBL IDCHEMBL1237044
ChEBI ID75722
PubChem CID33741
DrugBankDB00193
UNII ID39J1LGJ30J (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 20,592 documents
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Safety
Black-box Warning
Black-box warning for: Conzip, Qdolo, Seglentis, Tramadol hydrochloride, Ultracet
Adverse Events
Top Adverse Reactions
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62,466 adverse events reported
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