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Timolide 10-25, Duotrav(timolol)
Azarga, Betimol, Combigan, Cosopt, DuoTrav, Ganfort, Istalol, Timolide, Timoptic (timolol) is a small molecule pharmaceutical. Timolol was first approved as Timolide 10-25 on 1982-01-01. It is used to treat angina pectoris, heart failure, hypertension, myocardial infarction, and open-angle glaucoma in the USA. It has been approved in Europe to treat ocular hypertension and open-angle glaucoma. The pharmaceutical is active against beta-2 adrenergic receptor.
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Novartis Pharmaceuticals
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Betimol, Istalol, Timoptic, Timoptic in ocudose, Timoptic-xe (generic drugs available since 1990-06-08, discontinued: Blocadren)
Combinations
Combigan, Cosopt (generic drugs available since 1990-06-08, discontinued: Timolide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Brimonidine tartrate
+
Timolol maleate
Tradename
Company
Number
Date
Products
COMBIGANAbbVieN-021398 RX2007-10-30
1 products, RLD, RS
Dorzolamide hydrochloride
+
Timolol maleate
Tradename
Company
Number
Date
Products
COSOPTThea PharmaN-020869 RX1998-04-07
1 products, RLD, RS
COSOPT PFThea PharmaN-202667 RX2012-02-01
1 products, RLD, RS
Hydrochlorothiazide
+
Timolol maleate
Tradename
Company
Number
Date
Products
TIMOLIDE 10-25Merck KGaAN-018061 DISCN1982-01-01
1 products
Hide discontinued
Timolol
Tradename
Company
Number
Date
Products
BETIMOLThea PharmaN-020439 RX1995-03-31
2 products, RLD, RS
Timolol maleate
Tradename
Company
Number
Date
Products
ISTALOLBausch Health CompaniesN-021516 RX2004-06-04
1 products, RLD, RS
TIMOPTICBausch Health CompaniesN-018086 RX1982-01-01
2 products, RLD
TIMOPTIC IN OCUDOSEBausch Health CompaniesN-019463 RX1986-11-05
2 products, RLD, RS
TIMOPTIC-XEBausch Health CompaniesN-020330 RX1993-11-04
2 products, RLD
TIMOLOL MALEATESandozN-020963 RX1998-10-21
2 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
betimolNew Drug Application2022-11-14
combiganNew Drug Application2015-10-01
cosopt pfNew Drug Application2022-11-08
dorzolamide hydrochloride and timolol maleateANDA2022-06-30
istalolNew Drug Application2019-10-31
timopticNew Drug Application2022-04-30
timoptic-xeNew Drug Application2021-02-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C07: Beta-adrenergic blocking agents
C07A: Beta blocking agents
C07AA: Beta blocking agents, non-selective
C07AA06: Timolol
C07B: Beta blocking agents and thiazides
C07BA: Beta blocking agents, non-selective, and thiazides
C07BA06: Timolol and thiazides
C07D: Beta blocking agents, thiazides and other diuretics
C07DA: Beta blocking agents, non-selective, thiazides and other diuretics
C07DA06: Timolol, thiazides and other diuretics
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01ED: Beta blocking agents, antiglaucoma preparations and miotics
S01ED01: Timolol
S01ED51: Timolol, combinations
HCPCS
No data
Clinical
Clinical Trials
270 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ocular hypertensionD009798EFO_1001069H40.0621644217145
Open-angle glaucomaD005902EFO_0004190H40.1621453915120
GlaucomaD005901EFO_0000516H403523451187
Healthy volunteers/patients21115
Low tension glaucomaD057066EFO_1001022H40.121315
Macular edemaD0082692113
Exfoliation syndromeD017889EFO_00042351113
Eye diseasesD005128EFO_0003966H4422
Anterior uveitisD014606EFO_100081111
Angle-closure glaucomaD01581211
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemangiomaD006391D18.012115
Macular degenerationD008268EFO_0001365H35.30212
Wet macular degenerationD057135EFO_0004683212
Surgical woundD000072836222
Visual acuityD01479211
Corneal edemaD015715EFO_1000879H18.2011
Diabetic footD017719EFO_100145911
MelanomaD00854511
Liver cirrhosisD008103EFO_0001422K74.011
Portal hypertensionD006975EFO_0000666K76.611
Show 1 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hereditary hemorrhagic telangiectasiaD013683I78.0213
Migraine disordersD008881EFO_0003821G43112
Retinal vein occlusionD012170EFO_1001157H34.8111
UlcerD014456MPATH_57911
BurnsD002056T30.011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acne vulgarisD000152EFO_0003894L70112
RosaceaD012393L7111
Ischemic optic neuropathyD018917EFO_1000809H47.0111
Sturge-weber syndromeD013341Orphanet_3205Q85.8911
Port-wine stainD019339Q82.511
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes complicationsD04890911
Ocular physiological phenomenaD00979911
Scleral bucklingD01259111
Retinal detachmentD012163EFO_0005773H33.211
Retinal perforationsD012167EFO_100102811
Intraocular pressureD00742911
ParonychiaD010304EFO_0007421L03.011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTIMOLOL
INNtimolol
Description
(S)-timolol (anhydrous) is the (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. It has a role as an antiglaucoma drug, an antihypertensive agent, an anti-arrhythmia drug and a beta-adrenergic antagonist. It is a conjugate base of a (S)-timolol(1+). It is an enantiomer of a (R)-timolol.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Identifiers
PDB
CAS-ID26839-75-8
RxCUI1546004
ChEMBL IDCHEMBL499
ChEBI ID9599
PubChem CID33624
DrugBankDB00373
UNII ID5JKY92S7BR (ChemIDplus, GSRS)
Target
Agency Approved
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Betimol - Akorn
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,897 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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717 adverse events reported
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