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Thiopental
Pentothal (thiopental) is a small molecule pharmaceutical. Thiopental was first approved as Pentothal on 1982-01-01. It is used to treat intracranial hypertension in the USA. It is known to target potassium voltage-gated channel subfamily C member 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thiopental sodium
Tradename
Company
Number
Date
Products
PENTOTHALAbbott BiotherapeuticsN-011679 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
intracranial hypertensionEFO_1000992D019586
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N01: Anesthetics
N01A: Anesthetics, general
N01AF: Barbiturates for general anesthesia, plain
N01AF03: Thiopental
N05: Psycholeptics
N05C: Hypnotics and sedatives
N05CA: Barbiturates, hypnotics and sedatives, plain
N05CA19: Thiopental
HCPCS
No data
Clinical
Clinical Trials
82 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0411176136
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C951920332
LymphomaD008223C85.9246
Myelodysplastic syndromesD009190D4666
Myeloid leukemia acuteD015470C92.055
Down syndromeD004314EFO_0001064Q90134
Brain neoplasmsD001932EFO_0003833C71112
Megakaryoblastic leukemia acuteD007947C94.222
Monocytic leukemia acuteD00794822
Myelomonocytic leukemia acuteD015479C92.522
Erythroblastic leukemia acuteD004915EFO_1001257C94.022
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_000051511
ThrombocytopeniaD013921HP_0001873D69.611
Non-hodgkin lymphomaD008228C85.9111
Langerhans-cell histiocytosisD006646C96.611
Hodgkin diseaseD006689C8111
NeoplasmsD009369C80111
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTHIOPENTAL
INNthiopental sodium
Description
Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. It is the thiobarbiturate analog of pentobarbital, and an analog of thiobarbital. Sodium thiopental was a core medicine in the World Health Organization's List of Essential Medicines, but was supplanted by propofol. Despite this, thiopental is listed as an acceptable alternative to propofol, depending on local availability and cost of these agents. It was previously the first of three drugs administered during most lethal injections in the United States, but the US manufacturer Hospira stopped manufacturing the drug in 2011 and the European Union banned the export of the drug for this purpose. Although thiopental abuse carries a dependency risk, its recreational use is rare.
Classification
Small molecule
Drug classBarbiturate
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
Identifiers
PDB
CAS-ID76-75-5
RxCUI
ChEMBL IDCHEMBL441
ChEBI ID102166
PubChem CID3000714
DrugBankDB00599
UNII ID49Y44QZL70 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNC4
KCNC4
Organism
Homo sapiens
Gene name
KCNC4
Gene synonyms
C1orf30
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 4
Protein synonyms
K+ channel subunit, KSHIIIC, potassium channel, voltage gated Shaw related subfamily C, member 4, potassium voltage-gated channel, Shaw-related subfamily, member 4, Voltage-gated potassium channel subunit Kv3.4
Uniprot ID
Mouse ortholog
Kcnc4 (99738)
potassium voltage-gated channel subfamily C member 4 (Q8R1C0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 14,996 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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2,328 adverse events reported
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