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Tegaserod
Zelnorm (tegaserod) is a small molecule pharmaceutical. Tegaserod was first approved as Zelnorm on 2002-07-24. It is used to treat constipation and irritable bowel syndrome in the USA. It is known to target 5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine receptor 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tegaserod maleate
Tradename
Company
Number
Date
Products
ZELNORMAlfasigmaN-021200 DISCN2002-07-24
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
zelnormNew Drug Application2020-06-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
constipationHP_0002019D003248K59.0
irritable bowel syndromeEFO_0000555D043183K58
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A06: Drugs for constipation
A06A: Drugs for constipation
A06AX: Other drugs for constipation in atc
A06AX06: Tegaserod
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R521613120
Low back painD017116HP_0003419M54.528313
OsteoarthritisD010003EFO_0002506M15-M191618
Postoperative painD010149G89.1842118
NeuralgiaD009437EFO_000943011226
Back painD001416HP_0003418M541225
Knee osteoarthritisD020370EFO_0004616M171315
Acute painD059787R5212115
Visceral painD05926511
Peripheral nervous system diseasesD010523G6411
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic painD059350HP_00125321517
NeoplasmsD009369C801416
Diabetic neuropathiesD003929EFO_1000783134
ArthralgiaD018771HP_0002829M25.544
Hallux valgusD006215HP_000182244
BunionD000071378M21.61123
Joint diseasesD007592HP_0003040M12.922
Pain measurementD01014722
Nociceptive painD05922611
ArthritisD001168EFO_0005856M05-M1411
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postherpetic neuralgiaD05147411
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients77
PharmacokineticsD01059944
HyperalgesiaD00693011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnalgesiaD00069822
Cancer painD000072716G89.311
Substance abuse detectionD01581311
Procedural painD00007381811
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTEGASEROD
INNtegaserod
Description
Tegaserod is a member of guanidines, a carboxamidine, a member of hydrazines and a member of indoles. It has a role as a serotonergic agonist and a gastrointestinal drug.
Classification
Small molecule
Drug classserotonin receptor antagonists and partial agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12
Identifiers
PDB
CAS-ID145158-71-0
RxCUI139778
ChEMBL IDCHEMBL76370
ChEBI ID51043
PubChem CID135409453
DrugBankDB01079
UNII ID458VC51857 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR2B
HTR2B
HTR4
HTR4
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,224 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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29,522 adverse events reported
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