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Tazarotene
Arazlo, Avage, Duobrii, Fabior, Tazorac (tazarotene) is a small molecule pharmaceutical. Tazarotene was first approved as Tazorac on 1997-06-13. It is used to treat acne vulgaris and psoriasis in the USA. The pharmaceutical is active against retinoic acid receptor beta, retinoic acid receptor alpha, and retinoic acid receptor gamma. In addition, it is known to target chemerin-like receptor 1 and chemerin-like receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Arazlo, Avage, Fabior, Tazorac (generic drugs available since 2017-04-03)
Combinations
Duobrii
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Halobetasol propionate
+
Tazarotene
Tradename
Company
Number
Date
Products
DUOBRIIBausch Health CompaniesN-209354 RX2019-04-25
1 products, RLD, RS
Tazarotene
Tradename
Company
Number
Date
Products
TAZORACAllerganN-020600 RX1997-06-13
2 products, RLD, RS
AVAGEAllerganN-021184 RX2002-09-30
1 products, RLD, RS
TAZORACAllerganN-021184 RX2000-09-29
2 products, RLD, RS
ARAZLOBausch Health CompaniesN-211882 RX2019-12-18
1 products, RLD, RS
FABIORMayne GroupN-202428 RX2012-05-11
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
arazloNew Drug Application2019-12-19
duobriiNew Drug Application2020-01-01
fabiorNew Drug Application2018-06-30
tazaroteneANDA2023-05-17
tazoracNew Drug Application2022-12-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
psoriasisEFO_0000676D011565L40
Agency Specific
FDA
EMA
Expiration
Code
TAZAROTENE, TAZAROTENE, COSETTE
2023-03-13CGT
Patent Expiration
Patent
Expires
Flag
FDA Information
Tazarotene, Arazlo, Bausch
113114822038-05-11U-2368
Halobetasol Propionate / Tazarotene, Duobrii, Bausch
102518952036-06-06DP
104267872036-06-06U-2625
88093072031-11-02DP
104785022031-11-02DPU-2625
Tazarotene, Fabior, Mayne Pharma
88087162030-02-24DP
105688592030-02-24DPU-2760
106880712030-02-24DPU-2760
ATC Codes
D: Dermatologicals
— D05: Antipsoriatics
— D05A: Antipsoriatics for topical use
— D05AX: Other antipsoriatics for topical use in atc
— D05AX05: Tazarotene
— D05AX55: Tazarotene and ulobetasol
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OnychomycosisD014009B35.11521—9
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTAZAROTENE
INNtazarotene
Description
Tazarotene is the ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin. It has a role as a keratolytic drug, a prodrug and a teratogenic agent. It is a retinoid, a thiochromane, a member of pyridines, an acetylenic compound and an ethyl ester. It is functionally related to a tazarotenic acid.
Classification
Small molecule
Drug classarotinoid derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCS3)nc1
Identifiers
PDB—
CAS-ID118292-40-3
RxCUI83947
ChEMBL IDCHEMBL1657
ChEBI ID32184
PubChem CID5381
DrugBankDB00799
UNII ID81BDR9Y8PS (ChemIDplus, GSRS)
Target
Agency Approved
RARB
RARB
RARA
RARA
RARG
RARG
Organism
Homo sapiens
Gene name
RARB
Gene synonyms
HAP, NR1B2
NCBI Gene ID
5915
Protein name
retinoic acid receptor beta
Protein synonyms
HBV-activated protein, hepatitis B virus activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-beta, RAR-epsilon, retinoic acid receptor, beta polypeptide
Uniprot ID
P10826
Mouse ortholog
Rarb (218772)
retinoic acid receptor beta (P22605)
Alternate
CMKLR1
CMKLR1
CMKLR2
CMKLR2
Organism
Homo sapiens
Gene name
CMKLR1
Gene synonyms
CHEMR23, DEZ
NCBI Gene ID
1240
Protein name
chemerin-like receptor 1
Protein synonyms
chemerin receptor, chemokine receptor-like 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, orphan G-protein coupled receptor, Dez, resolvin E1 receptor
Uniprot ID
Q99789
Mouse ortholog
Cmklr1 (14747)
chemerin-like receptor 1 (P97468)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,738 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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683 adverse events reported
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