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Succimer
Chemet (succimer) is a small molecule pharmaceutical. Succimer was first approved as Chemet on 1991-01-30. It is used to treat nervous system lead poisoning childhood in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
chemically-induced disordersD064419
Trade Name
FDA
EMA
Chemet
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Succimer
Tradename
Company
Number
Date
Products
CHEMETRecordatiN-019998 RX1991-01-30
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
chemetNew Drug Application2019-12-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
nervous system lead poisoning childhood—D020264—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09C: Renal system diagnostic radiopharmaceuticals
— V09CA: Technetium (99mtc) compounds
— V09CA02: Technetium (99mtc) succimer
— V09I: Tumour detection radiopharmaceuticals
— V09IA: Technetium (99mtc) compounds
— V09IA03: Technetium (99mtc) pentavalent succimer
HCPCS
Code
Description
A9551
Technetium tc-99m succimer, diagnostic, per study dose, up to 10 millicuries
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autistic disorderD001321EFO_0003758F84.011———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D461————1
Myeloid leukemia acuteD015470C92.01————1
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_00003401————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lead poisoningD007855T56.0————22
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSUCCIMER
INNsuccimer
Description
Succimer is a sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning. It has a role as a chelator. It is a dicarboxylic acid, a dithiol and a sulfur-containing carboxylic acid.
Classification
Small molecule
Drug classpolymers
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)[C@H](S)[C@H](S)C(=O)O
Identifiers
PDB—
CAS-ID304-55-2
RxCUI3446
ChEMBL IDCHEMBL1201073
ChEBI ID63623
PubChem CID2724354
DrugBankDB00566
UNII IDDX1U2629QE (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 599 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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111 adverse events reported
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