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Streptokinase
Streptokinase is an enzyme pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
arterial occlusive diseasesEFO_0009085D001157
myocardial infarctionEFO_0000612D009203I21
pulmonary embolismEFO_0003827D011655I26
venous thrombosisHP_0004936D020246I82.40
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B01: Antithrombotic agents
B01A: Antithrombotic agents
B01AD: Enzymes, antithrombotic
B01AD01: Streptokinase
B06: Other hematological agents in atc
B06A: Other hematological agents in atc
B06AA: Enzymes, hematological
B06AA55: Streptokinase, combinations
HCPCS
Code
Description
J2995
Injection, streptokinase, per 250,000 iu
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute coronary syndromeD054058EFO_0005672112
Pulmonary embolismD011655EFO_0003827I26112
Inferior wall myocardial infarctionD056989EFO_1000983112
Pleural effusionD010996J9011
Respiratory tract infectionsD012141J06.911
Reperfusion injuryD01542711
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myocardial infarctionD009203EFO_0000612I2133
Cardiovascular diseasesD002318EFO_0000319I9822
Coronary diseaseD00332722
Myocardial ischemiaD017202EFO_1001375I20-I2522
Heart diseasesD006331EFO_0003777I51.922
Respiratory distress syndromeD012128EFO_1000637J8011
PancreatitisD010195EFO_0000278K85111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ischemic strokeD00008324211
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
St elevation myocardial infarctionD00007265711
Non-st elevated myocardial infarctionD00007265811
Unstable anginaD000789EFO_1000985I20.011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSTREPTOKINASE
INNstreptokinase
Description
Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism. As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI). It is given by injection into a vein.
Classification
Enzyme
Drug classenzymes
Image (chem structure or protein)STREPTOKINASE
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB1BML, 1C4P, 1L4D, 1L4Z, 1QQR
CAS-ID9002-01-1
RxCUI10106
ChEMBL IDCHEMBL2108147
ChEBI ID
PubChem CID
DrugBankDB00086
UNII ID8X1OXL3SNU (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,380 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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