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Selegiline
Emsam, Zelapar (selegiline) is a small molecule pharmaceutical. Selegiline was first approved as Selegiline hydrochloride on 1989-06-05. It is used to treat alzheimer disease, attention deficit disorder with hyperactivity, depressive disorder, parkinson disease, and schizophrenia in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] B. In addition, it is known to target amine oxidase [flavin-containing] A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
mental disordersD001523
Trade Name
FDA
EMA
Emsam, Zelapar (generic drugs available since 1997-04-01, discontinued: Eldepryl)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Selegiline
Tradename
Company
Number
Date
Products
EMSAMSomerset PharmaN-021336 RX2006-02-27
3 products, RLD
Selegiline hydrochloride
Tradename
Company
Number
Date
Products
ZELAPARBausch Health CompaniesN-021479 RX2006-06-14
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
emsamNew Drug Application2020-05-15
selegiline hydrochlorideANDA2023-03-03
zelaparNew Drug Application2021-06-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alzheimer diseaseEFO_0000249D000544F03
attention deficit disorder with hyperactivityEFO_0003888D001289F90
depressive disorderEFO_1002014D003866F32.A
parkinson diseaseEFO_0002508D010300G20
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N04: Anti-parkinson drugs
N04B: Dopaminergic agents
N04BD: Mao b inhibitors, dopaminergic anti-parkinson drugs
N04BD01: Selegiline
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G2044
Healthy volunteers/patients213
Erectile dysfunctionD007172EFO_0004234F52.2111
Bipolar disorderD001714EFO_0000289F30.911
Major depressive disorderD003865EFO_0003761F2211
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F141416
Borderline personality disorderD001883HP_0012076F60.311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20213
Tobacco use disorderD014029F17213
Prostatic neoplasmsD011471C6111
Castration-resistant prostatic neoplasmsD06412911
Cognition disordersD00307211
Marijuana abuseD002189EFO_0007191F1211
Tobacco use cessationD02034011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F0311
SchizophreniaD012559EFO_0000692F2011
Amphetamine-related disordersD019969EFO_0004701F1511
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSELEGILINE
INNselegiline
Description
(-)-selegiline is a selegiline and a terminal acetylenic compound. It has a role as a geroprotector. It is a conjugate base of a (-)-selegiline(1+).
Classification
Small molecule
Drug classMonoamine oxidase (MAO) inhibitors, type B
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C#CCN(C)[C@H](C)Cc1ccccc1
Identifiers
PDB
CAS-ID14611-51-9
RxCUI9639
ChEMBL IDCHEMBL972
ChEBI ID9086
PubChem CID26757
DrugBankDB01037
UNII ID2K1V7GP655 (ChemIDplus, GSRS)
Target
Agency Approved
MAOB
MAOB
Organism
Homo sapiens
Gene name
MAOB
Gene synonyms
NCBI Gene ID
Protein name
amine oxidase [flavin-containing] B
Protein synonyms
adrenalin oxidase, MAO, brain, MAO, platelet, MAO-B, Monoamine oxidase type B, tyramine oxidase
Uniprot ID
Mouse ortholog
Maob (109731)
amine oxidase [flavin-containing] B (Q8C0B2)
Alternate
MAOA
MAOA
Organism
Homo sapiens
Gene name
MAOA
Gene synonyms
NCBI Gene ID
Protein name
amine oxidase [flavin-containing] A
Protein synonyms
MAO-A, Monoamine oxidase type A
Uniprot ID
Mouse ortholog
Maoa (17161)
amine oxidase [flavin-containing] A (Q8K0Z8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,514 documents
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Safety
Black-box Warning
Black-box warning for: Emsam
Adverse Events
Top Adverse Reactions
Mock data
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90,104 adverse events reported
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