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Rescinnamine
Cinnasil, Moderil (rescinnamine) is a small molecule pharmaceutical. Rescinnamine was first approved as Moderil on 1982-01-01. It is used to treat hypertension in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rescinnamine
Tradename
Company
Number
Date
Products
MODERILMylanN-010686 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C02: Antihypertensives
C02A: Antiadrenergic agents, centrally acting
C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic
C02AA01: Rescinnamine
C02L: Antihypertensives and diuretics in combination
C02LA: Rauwolfia alkaloids and diuretics in combination
C02LA02: Rescinnamine and diuretics
C02LA52: Rescinnamine and diuretics, combinations with other drugs
HCPCS
No data
Clinical
Clinical Trials
446 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnesthesiaD000758237143055
PainD010146EFO_0003843R52292233
Postoperative painD010149G89.18171624
General anesthesiaD000768114915
HyperalgesiaD00693027413
AnalgesiaD00069831610
Chronic painD059350HP_0012532347
Conscious sedationD0162921247
BronchoscopyD001999257
CoughD003371HP_0012735R05257
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug-related side effects and adverse reactionsD064420T88.71124
PregnancyD011247EFO_0002950Z33.11113
Opioid-related disordersD009293EFO_0005611F11112
StrokeD020521EFO_0000712I63.9112
Breast diseasesD001941N60-N65112
Breech presentationD001946HP_000162311
Vaginal hysterectomyD00704511
Suburethral slingsD05382511
Child developmentD00265711
Postpartum depressionD019052EFO_0007453F53.0111
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug overdoseD0627871112
NeoplasmsD009369C801112
HysterectomyD007044EFO_000388111
Hallux valgusD006215HP_000182211
Ventilator weaningD01530011
RespirationD012119111
Cesarean sectionD002585111
Hematologic diseasesD006402EFO_0005803D75.9111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Opiate overdoseD00008368211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nociceptive painD05922677
Brain neoplasmsD001932EFO_0003833C7133
Stomach neoplasmsD013274EFO_0003897C1622
Female genital diseasesD005831EFO_0009549N8522
Cardiac arrhythmiasD001145EFO_0004269I49.922
Colorectal neoplasmsD01517922
Traumatic brain injuriesD000070642S0622
HyperventilationD006985HP_0002883R06.422
EpilepsyD004827EFO_0000474G40.911
Inguinal herniaD006552HP_0000023K4011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRESCINNAMINE
INNrescinnamine
Description
Rescinnamine is a methyl ester, an organic heteropentacyclic compound and an indole alkaloid. It has a role as an antihypertensive agent. It derives from a hydride of a yohimban.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)/C=C/c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC
Identifiers
PDB
CAS-ID24815-24-5
RxCUI9259
ChEMBL IDCHEMBL1668
ChEBI ID28572
PubChem CID5280954
DrugBankDB01180
UNII IDQ6W1F7DJ2D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 151 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,886 adverse events reported
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