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Ramipril
Altace (ramipril) is a small molecule pharmaceutical. Ramipril was first approved as Altace on 1991-01-28. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
Altace (generic drugs available since 2005-10-24)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ramipril
Tradename
Company
Number
Date
Products
ALTACEKing PharmaceuticalsN-019901 RX1991-01-28
4 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
altaceNew Drug Application2020-06-10
ramiprilANDA2023-05-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic nephropathiesEFO_0000401D003928
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
left ventricular dysfunctionD018487
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C09: Agents acting on the renin-angiotensin system
C09A: Ace inhibitors, plain
C09AA: Ace inhibitors, plain
C09AA05: Ramipril
C09B: Ace inhibitors, combinations
C09BA: Ace inhibitors and diuretics
C09BA05: Ramipril and diuretics
C09BB: Ace inhibitors and calcium channel blockers
C09BB05: Ramipril and felodipine
C09BB07: Ramipril and amlodipine
C09BX: Ace inhibitors, other combinations in atc
C09BX03: Ramipril, amlodipine and hydrochlorothiazide
C09BX05: Ramipril and bisoprolol
C10: Lipid modifying agents
C10B: Lipid modifying agents, combinations
C10BX: Lipid modifying agents in combination with other drugs
C10BX04: Simvastatin, acetylsalicylic acid and ramipril
C10BX06: Atorvastatin, acetylsalicylic acid and ramipril
C10BX17: Rosuvastatin and ramipril
C10BX18: Atorvastatin, amlodipine and ramipril
HCPCS
No data
Clinical
Clinical Trials
75 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep initiation and maintenance disordersD007319F51.01241512336
DeliriumD003693R41.01517
Bipolar disorderD001714EFO_0000289F30.9415
Sleep wake disordersD012893G471113
SchizophreniaD012559EFO_0000692F2022
Sleep deprivationD012892F51.12112
Rem sleep behavior disorderD020187EFO_0007462G47.52112
Migraine disordersD008881EFO_0003821G43112
Chronobiology disordersD021081112
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9112
Show 9 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Obstructive sleep apneaD020181EFO_0003918G47.331113
AsthmaD001249EFO_0000270J4511
Gastroesophageal refluxD005764EFO_0003948K2111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.111
Lung injuryD055370S27.3011
Tobacco use disorderD014029F1711
Delayed emergence from anesthesiaD05519111
Neurocognitive disordersD019965F0911
Migraine without auraD020326EFO_0005296G43.011
Migraine with auraD020325EFO_0005295G43.111
Circadian rhythm sleep disordersD020178G47.211
Substance-related disordersD019966EFO_0003890F1311
BurnsD002056T30.011
Show 1 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Marijuana abuseD002189EFO_0007191F1211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinsonian disordersD020734HP_000130011
Healthy volunteers/patients11
NeuralgiaD009437EFO_000943011
Panic disorderD016584EFO_0004262F41.011
DementiaD003704F0311
Huntington diseaseD006816G1011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRAMIPRIL
INNramipril
Description
Ramipril is a dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug, a cardioprotective agent, a matrix metalloproteinase inhibitor and a bradykinin receptor B2 agonist. It is a dicarboxylic acid monoester, an azabicycloalkane, a cyclopentapyrrole, a dipeptide and an ethyl ester.
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCC[C@@H]21
Identifiers
PDB
CAS-ID87333-19-5
RxCUI35296
ChEMBL IDCHEMBL1168
ChEBI ID8774
PubChem CID5362129
DrugBankDB00178
UNII IDL35JN3I7SJ (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 11,544 documents
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Safety
Black-box Warning
Black-box warning for: Altace, Ramipril
Adverse Events
Top Adverse Reactions
Mock data
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3,447 adverse events reported
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