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Protriptyline
Vivactil (protriptyline) is a small molecule pharmaceutical. Protriptyline was first approved as Vivactil on 1982-01-01. It is used to treat depressive disorder and psychotic affective disorders in the USA. The pharmaceutical is active against sodium-dependent noradrenaline transporter and sodium-dependent serotonin transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Protriptyline hydrochloride
Tradename
Company
Number
Date
Products
VIVACTILTevaN-016012 DISCN1982-01-01
2 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
protriptyline hydrochlorideANDA2023-01-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
psychotic affective disorders—D000341F39
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA11: Protriptyline
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROTRIPTYLINE
INNprotriptyline
Description
Protriptyline is a carbotricyclic compound. It has a role as an antidepressant. It derives from a hydride of a dibenzo[a,d][7]annulene.
Classification
Small molecule
Drug classantidepressants (dibenzol[a,d]cycloheptane derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNCCCC1c2ccccc2C=Cc2ccccc21
Identifiers
PDB—
CAS-ID438-60-8
RxCUI8886
ChEMBL IDCHEMBL668
ChEBI ID8597
PubChem CID4976
DrugBankDB00344
UNII ID4NDU154T12 (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A2
SLC6A2
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
6530
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Q96KH8
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
Black-box warning for: Protriptyline hydrochloride
Adverse Events
Top Adverse Reactions
0 adverse events reported
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