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Propylthiouracil
Propylthiouracil is a small molecule pharmaceutical. Propylthiouracil was first approved as Propylthiouracil on 1982-01-01. It is used to treat goiter and thyroid crisis in the USA. The pharmaceutical is active against thyroid peroxidase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propylthiouracil
Tradename
Company
Number
Date
Products
PROPYLTHIOURACILDava PharmaceuticalsN-006188 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
propylthiouracilANDA2023-05-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
goiterEFO_0004283D006042E04.9
thyroid crisisEFO_1001212D013958E05.5
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H03: Thyroid therapy drugs
— H03B: Antithyroid preparations
— H03BA: Thiouracil antithyroid preparations
— H03BA02: Propylthiouracil
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROPYLTHIOURACIL
INNpropylthiouracil
Description
6-propyl-2-thiouracil is a pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. It has a role as an antithyroid drug, a carcinogenic agent, an antimetabolite, a hormone antagonist, an EC 1.14.13.39 (nitric oxide synthase) inhibitor, an antioxidant and an antidote to paracetamol poisoning. It is functionally related to a uracil.
Classification
Small molecule
Drug classuracil type antineoplastics; uracil derivatives used as thyroid antagonists and as antineoplastics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCc1cc(=O)[nH]c(=S)[nH]1
Identifiers
PDB5HPW
CAS-ID51-52-5
RxCUI8794
ChEMBL IDCHEMBL1518
ChEBI ID8502
PubChem CID657298
DrugBankDB00550
UNII ID721M9407IY (ChemIDplus, GSRS)
Target
Agency Approved
TPO
TPO
Organism
Homo sapiens
Gene name
TPO
Gene synonyms
NCBI Gene ID
7173
Protein name
thyroid peroxidase
Protein synonyms
thyroid microsomal antigen, thyroperoxidase
Uniprot ID
Q8TCI9
Mouse ortholog
Tpo (22018)
thyroid peroxidase (Q8C8B1)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
Black-box warning for: Propylthiouracil
Adverse Events
Top Adverse Reactions
0 adverse events reported
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