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Inderide-40/25, Hemangiol(propranolol)
Hemangeol, Hemangiol, Inderal, Inderide, Inderide-, Innopran (propranolol) is a small molecule pharmaceutical. Propranolol was first approved as Inderide-40/25 on 1982-01-01. It is used to treat angina pectoris, esophageal and gastric varices, essential tremor, heart failure, and hypertension amongst others in the USA. It has been approved in Europe to treat hemangioma. The pharmaceutical is active against beta-1 adrenergic receptor, beta-2 adrenergic receptor, and beta-3 adrenergic receptor. In addition, it is known to target 5-hydroxytryptamine receptor 5A, hepatic sodium/bile acid cotransporter, and 5-hydroxytryptamine receptor 1A.
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Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
Hemangeol, Inderal, Innopran (generic drugs available since 1985-10-22)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrochlorothiazide
+
Propranolol hydrochloride
Tradename
Company
Number
Date
Products
INDERIDE LA 80/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 120/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE LA 160/50WyethN-019059 DISCN1985-07-03
1 products
INDERIDE-40/25WYETH PHARMS INCN-018031 DISCN1982-01-01
1 products, RLD
INDERIDE-80/25WYETH PHARMS INCN-018031 DISCN1982-01-01
1 products, RLD
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Propranolol hydrochloride
Tradename
Company
Number
Date
Products
INDERAL LAANI PHARMSN-018553 RX1983-04-19
4 products, RLD
INNOPRAN XLANI PHARMSN-021438 RX2003-03-12
2 products, RLD, RS
HEMANGEOLLaboratoires Pierre FabreN-205410 RX2014-03-14
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
hemangeolNew Drug Application2020-04-22
inderal xlNew Drug Application2021-09-15
innopran xlNew Drug Application2019-06-10
propranolol hydrochlorideANDA2023-06-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
esophageal and gastric varicesEFO_0009545D004932I85
essential tremorEFO_0003108D020329G25.0
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
panic disorderEFO_0004262D016584F41.0
pheochromocytomaD010673
supraventricular tachycardiaHP_0004755D013617I47.1
ventricular fibrillationEFO_0004287D014693I49.01
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Propranolol Hydrochloride, Hemangeol, Pierre Fabre Derma
83384892028-10-16U-1496
89872622028-10-16U-1988
ATC Codes
C: Cardiovascular system drugs
C07: Beta-adrenergic blocking agents
C07A: Beta blocking agents
C07AA: Beta blocking agents, non-selective
C07AA05: Propranolol
C07B: Beta blocking agents and thiazides
C07BA: Beta blocking agents, non-selective, and thiazides
C07BA05: Propranolol and thiazides
C07F: Beta blocking agents, other combinations
C07FX: Beta blocking agents, other combinations
C07FX01: Propranolol and other combinations
HCPCS
Code
Description
J1800
Injection, propranolol hcl, up to 1 mg
Clinical
Clinical Trials
287 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Post-traumatic stress disordersD013313EFO_0001358F43.121355325
Liver cirrhosisD008103EFO_0001422K74.0489623
Portal hypertensionD006975EFO_0000666K76.6232712
Esophageal and gastric varicesD004932EFO_0009545I8536110
HemangiomaD006391D18.0142118
Traumatic brain injuriesD000070642S0623138
Migraine disordersD008881EFO_0003821G4311226
Postural orthostatic tachycardia syndromeD054972G90.A11114
Liver neoplasmsD008113EFO_1001513C22.01124
Psychological stressD0133152113
Show 25 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients1131317
Retinopathy of prematurityD012178EFO_1001158H35.116117
BurnsD002056T30.06517
MelanomaD0085451213
Supraventricular tachycardiaD013617HP_0004755I47.1123
Cardiovascular diseasesD002318EFO_0000319I98123
Adjustment disordersD000275F43.2313
Trauma and stressor related disordersD000068099F43.9313
StrokeD020521EFO_0000712I63.9313
Migraine without auraD020326EFO_0005296G43.0122
Show 21 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F142417
Orthostatic intoleranceD0549712113
Breast neoplasmsD001943EFO_0003869C50123
Cavernous hemangioma central nervous systemD020786EFO_1001343123
Traumatic stress disorders acuteD040701EFO_0005223F43.033
FibromyalgiaD005356EFO_0005687M79.1123
Multiple myelomaD009101C90.0213
Type 1 diabetes mellitusD003922EFO_0001359E10112
HemangiosarcomaD006394122
Autism spectrum disorderD000067877F84.0112
Show 53 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VasodilationD014664213
ObesityD009765EFO_0001073E66.9112
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.922
Ovarian epithelial carcinomaD00007721622
Fallopian tube neoplasmsD00518522
Kidney diseasesD007674EFO_0003086N0811
Stem cell transplantationD03358111
HypoglycemiaD007003HP_0001943E16.211
Prediabetic stateD011236EFO_1001121R73.0311
Metabolic syndromeD024821EFO_0000195E88.8111
Show 18 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.022
Autistic disorderD001321EFO_0003758F84.022
Diabetes mellitusD003920EFO_0000400E08-E1311
Insulin resistanceD007333EFO_000261411
Orthodontic extrusionD05079311
Exercise testD005080EFO_000432811
Uterine cervical neoplasmsD00258311
Heroin dependenceD006556EFO_000424011
Pain measurementD01014711
FibrosisD00535511
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROPRANOLOL
INNpropranolol
Description
Propranolol is a propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3. It has a role as a beta-adrenergic antagonist, an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, an antihypertensive agent, a xenobiotic, an environmental contaminant and a human blood serum metabolite. It is a secondary amine, a propanolamine and a member of naphthalenes. It is functionally related to a 1-naphthol.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)COc1cccc2ccccc12
Identifiers
PDB
CAS-ID525-66-6
RxCUI
ChEMBL IDCHEMBL27
ChEBI ID8499
PubChem CID4946
DrugBankDB00571
UNII ID9Y8NXQ24VQ (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
ADRB2
ADRB2
ADRB3
ADRB3
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
HTR5A
HTR5A
SLC10A1
SLC10A1
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR5A
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 5A
Protein synonyms
5-HT-5, 5-HT-5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled, Serotonin receptor 5A
Uniprot ID
Mouse ortholog
Htr5a (15563)
5-hydroxytryptamine receptor 5A (Q3URB0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 37,224 documents
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Safety
Black-box Warning
Black-box warning for: Innopran xl
Adverse Events
Top Adverse Reactions
Mock data
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695 adverse events reported
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