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Prochlorperazine
Compazine (prochlorperazine) is a small molecule pharmaceutical. Prochlorperazine was first approved as Compazine on 1982-01-01. It is used to treat anxiety disorders, dementia, nausea, psychotic disorders, and schizophrenia amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor. In addition, it is known to target D(1A) dopamine receptor, D(4) dopamine receptor, and protein S100-A4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prochlorperazine
Tradename
Company
Number
Date
Products
COMPAZINEGSKN-011127 DISCN1982-01-01
3 products
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Prochlorperazine maleate
Tradename
Company
Number
Date
Products
COMPAZINEGSKN-010571 DISCN1982-01-01
3 products, RLD
COMPAZINEGSKN-011000 DISCN1982-01-01
4 products
COMPAZINEGSKN-021019 DISCN1999-10-06
2 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
compazineANDA2013-08-28
comproANDA2023-01-18
prochlorperazine edisylateANDA2023-05-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxiety disordersEFO_0006788D001008F41.1
dementiaHP_0000726D003704F03
nauseaHP_0002018D009325R11.0
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AB: Phenothiazines with piperazine structure, antipsychotics
— N05AB04: Prochlorperazine
HCPCS
Code
Description
J0780
Injection, prochlorperazine, up to 10 mg
Q0164
Prochlorperazine maleate, 5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
S0183
Prochlorperazine maleate, oral, 5 mg (for circumstances falling under the medicare statute, use q0164)
Clinical
Clinical Trials
64 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.91177—328
Central nervous system neoplasmsD016543369——16
Hodgkin diseaseD006689C81—55—111
Brain neoplasmsD001932EFO_0003833C71—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.9—1———1
GlioblastomaD005909EFO_0000515—1———1
Aids-related lymphomaD016483EFO_1001365—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ataxia telangiectasiaD001260Orphanet_100G11.3————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROCHLORPERAZINE
INNprochlorperazine
Description
Prochlorperazine is a member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. It has a role as an antiemetic, a dopaminergic antagonist, an alpha-adrenergic antagonist, a cholinergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and a dopamine receptor D2 antagonist. It is an organochlorine compound, a N-alkylpiperazine, a N-methylpiperazine and a member of phenothiazines. It derives from a hydride of a 10H-phenothiazine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
Identifiers
PDB3M0W
CAS-ID58-38-8
RxCUI8704
ChEMBL IDCHEMBL728
ChEBI ID8435
PubChem CID4917
DrugBankDB00433
UNII IDYHP6YLT61T (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
1814
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Q4VBM8
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
DRD1
DRD1
DRD4
DRD4
S100A4
S100A4
Organism
Homo sapiens
Gene name
DRD1
Gene synonyms
NCBI Gene ID
1812
Protein name
D(1A) dopamine receptor
Protein synonyms
Dopamine D1 receptor
Uniprot ID
Q4QRJ0
Mouse ortholog
Drd1 (13488)
D(1A) dopamine receptor (Q8C8P8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,753 documents
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Safety
Black-box Warning
Black-box warning for: Compazine, Compro, Prochlorperazine edisylate
Adverse Events
Top Adverse Reactions
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5,616 adverse events reported
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