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Probenecid
Benemid, Colbenemid, Polycillin-prb, Probampacin, Proben-c (probenecid) is a small molecule pharmaceutical. Probenecid was first approved as Principen w/ probenecid on 1982-01-01. It is used to treat gonorrhea, gout, and neurosyphilis in the USA. The pharmaceutical is active against solute carrier family 22 member 6. In addition, it is known to target solute carrier organic anion transporter family member 1C1 and transient receptor potential cation channel subfamily V member 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
nervous system diseasesD009422
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ampicillin
+
Ampicillin trihydrate
+
Probenecid
Tradename
Company
Number
Date
Products
PRINCIPEN W/ PROBENECIDBristol Myers SquibbN-050488 DISCN1982-01-01
1 products
POLYCILLIN-PRBBristol Myers SquibbN-050457 DISCN1982-01-01
1 products
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Colchicine
+
Probenecid
Tradename
Company
Number
Date
Products
COLBENEMIDMerck KGaAN-012383 DISCN1982-01-01
1 products, RLD
Hide discontinued
Probenecid
Tradename
Company
Number
Date
Products
BENEMIDMerck KGaAN-007898 DISCN1982-01-01
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
probalance hand sanitizer advancedOTC monograph not final2020-05-20
probenecidANDA2023-05-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gonorrheaDOID_7551D006069A54
goutEFO_0004274D006073M10
neurosyphilisEFO_0007339D009494A50.4
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M04: Antigout preparations
— M04A: Antigout preparations
— M04AB: Preparations increasing uric acid excretion
— M04AB01: Probenecid
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Therapeutic equivalencyD0138101————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.9————11
Essential tremorD020329EFO_0003108G25.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROBENECID
INNprobenecid
Description
Probenecid is a sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. It has a role as a uricosuric drug. It is a sulfonamide and a member of benzoic acids.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCN(CCC)S(=O)(=O)c1ccc(C(=O)O)cc1
Identifiers
PDB—
CAS-ID57-66-9
RxCUI8698
ChEMBL IDCHEMBL897
ChEBI ID8426
PubChem CID4911
DrugBankDB01032
UNII IDPO572Z7917 (ChemIDplus, GSRS)
Target
Agency Approved
SLC22A6
SLC22A6
Organism
Homo sapiens
Gene name
SLC22A6
Gene synonyms
OAT1, PAHT
NCBI Gene ID
9356
Protein name
solute carrier family 22 member 6
Protein synonyms
hOAT1, hPAHT, hROAT1, Organic anion transporter 1, PAH transporter, para-aminohippurate transporter, Renal organic anion transporter 1, solute carrier family 22 (organic anion transporter), member 6
Uniprot ID
Q9UEQ8
Mouse ortholog
Slc22a6 (18399)
solute carrier family 22 member 6 (Q8VC69)
Alternate
SLCO1C1
SLCO1C1
TRPV2
TRPV2
Organism
Homo sapiens
Gene name
SLCO1C1
Gene synonyms
OATP14, OATP1C1, OATPF, SLC21A14
NCBI Gene ID
53919
Protein name
solute carrier organic anion transporter family member 1C1
Protein synonyms
OAT-RP-5, OATP-14, OATP-F, OATP-RP5, OATP1C1, Organic anion transporter 1C1, Organic anion transporter F, Organic anion transporter polypeptide-related protein 5, organic anion transporting polypeptide 14, Organic anion-transporting polypeptide 14, solute carrier family 21 (organic anion transporter), member 14, Solute carrier family 21 member 14, Thyroxine transporter
Uniprot ID
Q9NYB5
Mouse ortholog
Slco1c1 (58807)
solute carrier organic anion transporter family member 1C1 (Q9ERB5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 9,687 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,668 adverse events reported
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