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Prazepam
Centrax (prazepam) is a small molecule pharmaceutical. Prazepam was first approved as Centrax on 1982-01-01. It is used to treat alcohol withdrawal delirium, anxiety disorders, duodenal ulcer, muscle spasticity, and partial epilepsies in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
digestive system diseasesD004066
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Prazepam
Tradename
Company
Number
Date
Products
CENTRAXPfizerN-017415 DISCN1982-01-01
1 products
CENTRAXPfizerN-018144 DISCN1982-01-01
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alcohol withdrawal deliriumEFO_1000800D000430
anxiety disordersEFO_0006788D001008F41.1
duodenal ulcerEFO_0004607D004381K26
muscle spasticityHP_0001257D009128
partial epilepsiesEFO_0004263D004828
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N05: Psycholeptics
N05B: Anxiolytics
N05BA: Benzodiazepine derivative anxiolytics
N05BA11: Prazepam
HCPCS
No data
Clinical
Clinical Trials
412 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0112082239
Septic shockD012772A48.317125426
Adrenal insufficiencyD0003094338320
SepsisD018805A41.9463719
Atopic dermatitisD003876EFO_0000274L20165315
Congenital adrenal hyperplasiaD000312E25.04723115
Post-traumatic stress disordersD013313EFO_0001358F43.123914
Healthy volunteers/patients51129
Addison diseaseD000224E27.1151139
PsoriasisD011565EFO_0000676L4012317
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C9511210224
Prostatic neoplasmsD011471C612115117
LymphomaD008223C85.96612
Myeloid leukemia acuteD015470C92.063210
Myelodysplastic syndromesD009190D46336
Heart arrestD006323EFO_0009492I4622226
Covid-19D000086382U07.1235
PneumoniaD011014EFO_0003106J18314
Bronchopulmonary dysplasiaD001997P27.8224
Major depressive disorderD003865EFO_0003761F222124
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E101124
HemorrhoidsD006484EFO_0009552K64314
Down syndromeD004314EFO_0001064Q90213
NeoplasmsD009369C8033
Burkitt lymphomaD002051C83.7133
Opioid-related disordersD009293EFO_0005611F1133
Essential tremorD020329EFO_0003108G25.033
Biphenotypic leukemia acuteD015456C95.022
Head and neck neoplasmsD006258112
Breast neoplasmsD001943EFO_0003869C50112
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9325
Polycystic ovary syndromeD011085EFO_0000660E28.222
Hematologic neoplasmsD019337112
Blood pressureD001794EFO_000432522
T-cell lymphomaD01639922
Insulin resistanceD007333EFO_0002614112
Cocaine-related disordersD019970F14112
InfectionsD007239EFO_0000544112
RecurrenceD01200822
T-cell lymphoma peripheralD016411C84.911
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperaldosteronismD006929HP_0011736E2633
Inferior wall myocardial infarctionD056989EFO_100098322
Pituitary diseasesD010900E23.711
Circadian rhythm sleep disordersD020178G47.211
HypopituitarismD007018EFO_0001380E23.011
FeverD005334HP_0001945R50.911
Orthostatic hypotensionD007024I95.111
HypothermiaD007035HP_0002045T6811
Depressive disorderD003866EFO_1002014F32.A11
Esophageal stenosisD004940K22.211
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePRAZEPAM
INNprazepam
Description
Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Prazepam is a prodrug for desmethyldiazepam which is responsible for the therapeutic effects of prazepam.
Classification
Small molecule
Drug classantianxiety agents (diazepam type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1CC1CC1
Identifiers
PDB
CAS-ID2955-38-6
RxCUI8627
ChEMBL IDCHEMBL969
ChEBI ID8362
PubChem CID4890
DrugBankDB01588
UNII IDQ30VCC064M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 311 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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504 adverse events reported
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