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Polidocanol
Asclera, Varithena (polidocanol) is a small molecule pharmaceutical. Polidocanol was first approved as Asclera on 2010-03-30. It is used to treat varicose veins in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
Asclera, Varithena
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Polidocanol
Tradename
Company
Number
Date
Products
ASCLERAChemische Fabrik KreusslerN-021201 RX2010-03-30
2 products, RLD, RS
VARITHENAProvensisN-205098 RX2013-11-25
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ascleraNew Drug Application2022-02-01
varithenaNew Drug Application2020-08-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
varicose veinsHP_0002619D014648I83.90
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Polidocanol, Varithena, Provensis
94806522032-05-12DP
78149432027-11-19DPU-1461
77319862024-11-17DS, DPU-1463
81229172024-09-09DP
ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05B: Antivaricose therapy drugs
— C05BB: Sclerosing agents for local injection
— C05BB02: Polidocanol
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePOLIDOCANOL
INNlauromacrogol 400
Description
Polidocanol is a hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group. It has a role as a nonionic surfactant, a hepatotoxic agent and a sclerotherapy agent. It is functionally related to a nonaethylene glycol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Identifiers
PDB—
CAS-ID3055-99-0
RxCUI968170
ChEMBL IDCHEMBL1231723
ChEBI ID46859
PubChem CID656641
DrugBankDB06811
UNII ID0AWH8BFG9A (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,570 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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74 adverse events reported
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