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Piroxicam
Feldene (piroxicam) is a small molecule pharmaceutical. Piroxicam was first approved as Feldene on 1982-04-06. It is used to treat ankylosing spondylitis, inflammation, osteoarthritis, rheumatoid arthritis, and sunburn in the USA. It is known to target prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Feldene (generic drugs available since 1992-12-11)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Piroxicam
Tradename
Company
Number
Date
Products
FELDENEMylanN-018147 RX1982-04-06
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
feldeneNew Drug Application2020-08-21
piroxicamANDA2023-02-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ankylosing spondylitisEFO_0003898D013167M45
inflammationMP_0001845D007249
osteoarthritisEFO_0002506D010003M15-M19
rheumatoid arthritisEFO_0000685D001172M06.9
sunburnEFO_0003958D013471L55
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M01: Antiinflammatory and antirheumatic products
M01A: Antiinflammatory and antirheumatic products, non-steroids
M01AC: Oxicams, antiinflammatory and antirheumatic drugs
M01AC01: Piroxicam
M02: Topical products for joint and muscular pain
M02A: Topical products for joint and muscular pain
M02AA: Antiinflammatory preparations, non-steroids for topical use
M02AA07: Piroxicam
S: Sensory organ drugs
S01: Ophthalmologicals
S01B: Antiinflammatory agents, ophthalmologic
S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
S01BC06: Piroxicam
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients1113
Major depressive disorderD003865EFO_0003761F2211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Substance-related disordersD019966EFO_0003890F1311
Amphetamine-related disordersD019969EFO_0004701F1511
Mood disordersD019964EFO_0004247F30-F3911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I1011
Microvascular anginaD01756611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePIROXICAM
INNpiroxicam
Description
Piroxicam is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. It has a role as an analgesic, a cyclooxygenase 1 inhibitor, a non-steroidal anti-inflammatory drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an antirheumatic drug. It is a benzothiazine, a member of pyridines and a monocarboxylic acid amide.
Classification
Small molecule
Drug classanti-inflammatory agents (isoxicam type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O
Identifiers
PDB
CAS-ID36322-90-4
RxCUI8356
ChEMBL IDCHEMBL527
ChEBI ID8249
PubChem CID54676228
DrugBankDB00554
UNII ID13T4O6VMAM (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 5,973 documents
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Safety
Black-box Warning
Black-box warning for: Feldene, Piroxicam
Adverse Events
Top Adverse Reactions
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266 adverse events reported
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