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Phytonadione
Aquamephyton, Konakion, M.v.i, Mephyton, Vitamin K1, Vitaped (phytonadione) is a small molecule pharmaceutical. Phytonadione was first approved as Mephyton on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Phytonadione
Tradename
Company
Number
Date
Products
MEPHYTONBausch Health CompaniesN-010104 DISCN1982-01-01
1 products, RLD
AQUAMEPHYTONPAI PharmaN-012223 DISCN1982-01-01
2 products, RLD
KONAKIONRocheN-011745 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2016-10-28
mephytonNew Drug Application2020-11-17
phytonadioneANDA2022-12-29
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B02: Antihemorrhagics
B02B: Vitamin k and other hemostatics
B02BA: Vitamin k containing hemostatics
B02BA01: Phytomenadione
HCPCS
Code
Description
J3430
Injection, phytonadione (vitamin k), per 1 mg
Clinical
Clinical Trials
253 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients1111619
ObesityD009765EFO_0001073E66.9211013
Liver cirrhosisD008103EFO_0001422K74.0113712
Hepatic encephalopathyD006501K72.912248
Type 2 diabetes mellitusD003924EFO_0001360E11156
Muscular atrophyD009133HP_00032021124
PhenylketonuriasD010661E70.0123
InflammationD007249123
Colorectal neoplasmsD015179112
Iron-deficiency anemiaD018798HP_0001891D50112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Milk hypersensitivityD016269EFO_0007369111315
Neuroendocrine tumorsD018358EFO_1001901D3A.846210
MalnutritionD044342EFO_0008572E40-E4611810
Critical illnessD016638189
Nervous system diseasesD009422G00-G9911
Atopic dermatitisD003876EFO_0000274L2011
EczemaD004485HP_0000964L30.911
Dental plaqueD00377311
Covid-19D000086382U07.1111
Iron deficienciesD000090463E61.111
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuroblastomaD009447EFO_000062122
MedulloblastomaD00852722
MeningiomaD008579EFO_0003098D32.922
Neuroendocrine carcinomaD018278122
OsteoarthritisD010003EFO_0002506M15-M19112
Dental cariesD003731EFO_0003819K02112
Liver neoplasmsD008113EFO_1001513C22.0112
Respiratory insufficiencyD012131HP_0002093J96.9112
OverweightD050177E66.311
Pancreatic neoplasmsD010190EFO_0003860C25111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SarcopeniaD055948EFO_1000653M62.8421113
Insulin resistanceD007333EFO_0002614123
AgingD000375GO_0007568R41.81123
Acute-on-chronic liver failureD06529022
Pressure ulcerD003668L8911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic syndromeD024821EFO_0000195E88.8155
ExerciseD015444EFO_000048344
Food hypersensitivityD005512EFO_100189044
Weight lossD015431HP_000182433
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.933
Traumatic brain injuriesD000070642S0633
HyperglycemiaD006943HP_0003074R73.922
Ulcerative colitisD003093EFO_0000729K5122
Oxidative stressD018384EFO_100190522
Short bowel syndromeD01277822
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHYTONADIONE
INNphytomenadione
Description
Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a vitamin K and a member of phylloquinones.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1=C(C/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=O)c2ccccc2C1=O
Identifiers
PDB
CAS-ID84-80-0
RxCUI8308
ChEMBL IDCHEMBL1550
ChEBI ID18067
PubChem CID5284607
DrugBankDB01022
UNII IDA034SE7857 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Phytonadione - Amphastar Pharmaceuticals
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,058 documents
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Safety
Black-box Warning
Black-box warning for: Phytonadione
Adverse Events
Top Adverse Reactions
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192 adverse events reported
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