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Pentoxifylline
Pentoxil, Trental (pentoxifylline) is a small molecule pharmaceutical. Pentoxifylline was first approved as Trental on 1984-08-30. It is used to treat brain ischemia, cerebral malaria, diabetic angiopathies, diabetic neuropathies, and gangrene amongst others in the USA. It is known to target adenosine receptor A2b and cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pentoxifylline
Tradename
Company
Number
Date
Products
TRENTALValidus PharmaceuticalsN-018631 DISCN1984-08-30
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
pentoxifyllineANDA2023-05-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
brain ischemiaHP_0002637D002545I67.82
cerebral malariaD016779B50.0
diabetic angiopathiesEFO_1000896D003925
diabetic neuropathiesEFO_1000783D003929
gangreneEFO_0008574D005734R02
intermittent claudicationEFO_0003876D007383I73.9
strokeEFO_0000712D020521I63.9
thrombosisD013927
vasculitisEFO_0006803D014657M31
vasculogenic impotenceEFO_1001234D018783
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C04: Peripheral vasodilators
C04A: Peripheral vasodilators
C04AD: Purine derivatives, peripheral vasodilators
C04AD03: Pentoxifylline
HCPCS
No data
Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B202171020
Pneumocystis pneumoniaD011020EFO_0007448B592171020
Cutaneous leishmaniasisD016773B55.1313
LeishmaniasisD007896EFO_0005044B55111
Visceral leishmaniasisD007898B55.011
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179122
LymphomaD008223C85.911
Kidney diseasesD007674EFO_0003086N08111
Kidney transplantationD016030111
Type 1 diabetes mellitusD003922EFO_0001359E1011
Hypertrophic cicatrixD017439L91.0111
Non-small-cell lung carcinomaD00228911
Pancreatic neoplasmsD010190EFO_0003860C25111
African trypanosomiasisD014353B5611
MelanomaD00854511
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hodgkin diseaseD006689C8111
Liver neoplasmsD008113EFO_1001513C22.011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hematologic neoplasmsD01933711
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePENTOXIFYLLINE
INNpentoxifylline
Description
Pentoxifylline is an oxopurine.
Classification
Small molecule
Drug classtheophylline derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
Identifiers
PDB3TVX
CAS-ID6493-05-6
RxCUI8013
ChEMBL IDCHEMBL628
ChEBI ID7986
PubChem CID4740
DrugBankDB00806
UNII IDSD6QCT3TSU (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADORA2B
ADORA2B
PDE4A
PDE4A
Organism
Homo sapiens
Gene name
ADORA2B
Gene synonyms
NCBI Gene ID
Protein name
adenosine receptor A2b
Protein synonyms
Uniprot ID
Mouse ortholog
Adora2b (11541)
adenosine receptor A2b (Q8BXI2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,920 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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612 adverse events reported
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