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Oxytocin
Pitocin (oxytocin) is a protein pharmaceutical. Oxytocin was first approved as Oxytocin on 1982-01-01. It is used to treat postpartum hemorrhage in the USA. The pharmaceutical is active against oxytocin receptor. In addition, it is known to target vasopressin V1a receptor, vasopressin V2 receptor, and vasopressin V1b receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Pitocin (generic drugs available since 2013-02-13, discontinued: Syntocinon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxytocin
Tradename
Company
Number
Date
Products
OXYTOCINFresenius KabiN-018248 RX1982-01-01
3 products, RLD, RS
OXYTOCINHikma PharmaceuticalsN-018243 RX1982-01-01
2 products, RLD, RS
PITOCINPar PharmaceuticalN-018261 RX1982-01-01
3 products, RLD, RS
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
pitocinNew Drug Application2021-06-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
postpartum hemorrhage—D006473O72
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02A: Uterotonics
— G02AC: Ergot alkaloids and oxytocin incl. analogues, in combination
— G02AC01: Methylergometrine and oxytocin
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BB: Oxytocin and analogues
— H01BB02: Oxytocin
HCPCS
Code
Description
J2590
Injection, oxytocin, up to 10 units
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Wilms tumorD009396———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acne vulgarisD000152EFO_0003894L70——1——1
FurunculosisD005667L02.92——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOXYTOCIN
INNoxytocin
Description
Oxytocin is a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour. It has a role as an oxytocic and a vasodilator agent. It is a peptide hormone and a heterodetic cyclic peptide.
Classification
Protein
Drug classoxytocin derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
Identifiers
PDB—
CAS-ID50-56-6
RxCUI7824
ChEMBL IDCHEMBL395429
ChEBI ID7872
PubChem CID439302
DrugBankDB00107
UNII ID1JQS135EYN (ChemIDplus, GSRS)
Target
Agency Approved
OXTR
OXTR
Organism
Homo sapiens
Gene name
OXTR
Gene synonyms
NCBI Gene ID
5021
Protein name
oxytocin receptor
Protein synonyms
Uniprot ID
Q15071
Mouse ortholog
Oxtr (18430)
oxytocin receptor (P97926)
Alternate
AVPR1A
AVPR1A
AVPR2
AVPR2
AVPR1B
AVPR1B
Organism
Homo sapiens
Gene name
AVPR1A
Gene synonyms
AVPR1
NCBI Gene ID
552
Protein name
vasopressin V1a receptor
Protein synonyms
Antidiuretic hormone receptor 1a, AVPR V1a, SCCL vasopressin subtype 1a receptor, V1-vascular vasopressin receptor AVPR1A, V1a vasopressin receptor, Vascular/hepatic-type arginine vasopressin receptor
Uniprot ID
P37288
Mouse ortholog
Avpr1a (54140)
vasopressin V1a receptor (Q9QYH2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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294 adverse events reported
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