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Oxyphenbutazone
Tandearil (oxyphenbutazone) is a small molecule pharmaceutical. Oxyphenbutazone was first approved as Tandearil on 1982-09-03.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxyphenbutazone
Tradename
Company
Number
Date
Products
TANDEARILNovartisN-012542 DISCN1982-09-03
1 products
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
M01: Antiinflammatory and antirheumatic products
M01A: Antiinflammatory and antirheumatic products, non-steroids
M01AA: Butylpyrazolidines, antiinflammatory and antirheumatic drugs
M01AA03: Oxyphenbutazone
M02: Topical products for joint and muscular pain
M02A: Topical products for joint and muscular pain
M02AA: Antiinflammatory preparations, non-steroids for topical use
M02AA04: Oxyphenbutazone
S: Sensory organ drugs
S01: Ophthalmologicals
S01B: Antiinflammatory agents, ophthalmologic
S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
S01BC02: Oxyphenbutazone
HCPCS
No data
Clinical
Clinical Trials
32 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StomatitisD013280EFO_1001904K12.11113
CandidiasisD002177B37112
Chronic kidney failureD007676EFO_0003884N18.611
MycosesD009181B35-B4911
VaginitisD014627EFO_0005757N7611
Critical illnessD01663811
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B202147
Oral candidiasisD002180EFO_0007406B37.0235
Ventilator-associated pneumoniaD053717EFO_1001865J95.851111
BacteremiaD016470EFO_0003033R78.81111
Bacterial vaginosisD016585EFO_000393211
LeukemiaD007938C9511
Myelodysplastic syndromesD009190D4611
InfectionsD007239EFO_000054411
Myeloproliferative disordersD009196D47.111
LymphomaD008223C85.911
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Denture stomatitisD013282EFO_1000893K12.1112
Graft vs host diseaseD006086D89.8111
Kidney diseasesD007674EFO_0003086N08111
Kidney transplantationD016030111
Cross infectionD00342811
Anastomotic leakD05786811
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dental cariesD003731EFO_0003819K0211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Oral lichen planusD01767611
Periodontal diseasesD010510K05.611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOXYPHENBUTAZONE
INNoxyphenbutazone
Description
Oxyphenbutazone is a metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a gout suppressant, a drug metabolite, a xenobiotic metabolite, an antineoplastic agent and an antimicrobial agent. It is a member of pyrazolidines and a member of phenols. It is functionally related to a phenylbutazone.
Classification
Small molecule
Drug classanti-inflammatory analgesics (phenylbutazone type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCC1C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O.O
Identifiers
PDB
CAS-ID129-20-4
RxCUI7816
ChEMBL IDCHEMBL3989676
ChEBI ID
PubChem CID4641
DrugBankDB03585
UNII IDA7D84513GV (ChemIDplus, GSRS)
Target
Agency Approved
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Alternate
No data
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 600 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,803 adverse events reported
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