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Xenical(orlistat)
Alli, Xenical (orlistat) is a small molecule pharmaceutical. Orlistat was first approved as Xenical on 1998-07-29. It is used to treat obesity in the USA. It has been approved in Europe to treat obesity. The pharmaceutical is active against pancreatic triacylglycerol lipase. In addition, it is known to target diacylglycerol lipase-beta, diacylglycerol lipase-alpha, and lysophosphatidylserine lipase ABHD12.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Alli, Xenical
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Orlistat
Tradename
Company
Number
Date
Products
XENICALCHEPLAPHARM ArzneimittelN-020766 RX1999-04-23
1 products, RLD, RS
ALLIGSKN-021887 OTC2007-02-07
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
orlistatNDA authorized generic2023-01-06
xenicalNew Drug Application2020-11-25
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
obesityEFO_0001073D009765E66.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A08: Antiobesity preparations, excl. diet products
A08A: Antiobesity preparations, excl. diet products
A08AB: Peripherally acting antiobesity products
A08AB01: Orlistat
HCPCS
No data
Clinical
Clinical Trials
56 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.973101030
OverweightD050177E66.321169
Type 2 diabetes mellitusD003924EFO_0001360E11123
Polycystic ovary syndromeD011085EFO_0000660E28.2112
Fatty liverD00523422
BulimiaD002032F50.2112
Glucose intoleranceD018149HP_0000833R73.0311
Hepatitis cD006526B19.211
HepatitisD006505HP_0012115K75.911
Heart diseasesD006331EFO_0003777I51.911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Weight lossD015431HP_0001824112
Female infertilityD007247EFO_0008560N9711
AsthmaD001249EFO_0000270J4511
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic syndromeD024821EFO_0000195E88.811314
Diabetes mellitusD003920EFO_0000400E08-E13112
Nutrition disordersD009748EFO_000106911
Obstructive sleep apneaD020181EFO_0003918G47.3311
HypertensionD006973EFO_0000537I1011
Sleep apnea syndromesD012891EFO_0003877G47.311
HypertriglyceridemiaD015228EFO_000421111
Hyperlipoproteinemia type iD008072Orphanet_411E78.311
Hyperlipoproteinemia type vD006954Orphanet_70470E78.311
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnovulationD00085811
HyperlipidemiasD006949EFO_0003774E78.511
InfertilityD007246EFO_000054511
Feeding and eating disordersD001068F5011
Crigler-najjar syndromeD003414Orphanet_205E80.511
Therapeutic equivalencyD01381011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameORLISTAT
INNorlistat
Description
Orlistat is a carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. It has a role as an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, a bacterial metabolite, an EC 2.3.1.85 (fatty acid synthase) inhibitor and an anti-obesity agent. It is a beta-lactone, a L-leucine derivative, a member of formamides and a carboxylic ester.
Classification
Small molecule
Drug classenzyme inhibitors: gastrointestinal lipase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Identifiers
PDB
CAS-ID96829-58-2
RxCUI37925
ChEMBL IDCHEMBL175247
ChEBI ID
PubChem CID3034010
DrugBankDB01083
UNII ID95M8R751W8 (ChemIDplus, GSRS)
Target
Agency Approved
PNLIP
PNLIP
Organism
Homo sapiens
Gene name
PNLIP
Gene synonyms
NCBI Gene ID
Protein name
pancreatic triacylglycerol lipase
Protein synonyms
triacylglycerol acylhydrolase, triacylglycerol lipase
Uniprot ID
Mouse ortholog
Pnlip (69060)
pancreatic triacylglycerol lipase (Q6P8U6)
Alternate
DAGLB
DAGLB
DAGLA
DAGLA
ABHD12
ABHD12
Organism
Homo sapiens
Gene name
DAGLB
Gene synonyms
NCBI Gene ID
Protein name
diacylglycerol lipase-beta
Protein synonyms
DAGL-beta, DGL-beta, KCCR13L, PUFA-specific triacylglycerol lipase, Sn1-specific diacylglycerol lipase beta
Uniprot ID
Mouse ortholog
Daglb (231871)
diacylglycerol lipase-beta (Q91WC9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 28,148 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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720 adverse events reported
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