Norethynodrel
Enovid (norethynodrel) is a small molecule pharmaceutical. Norethynodrel was first approved as Enovid on 1982-01-01. It is used to treat amenorrhea, endometrial hyperplasia, female infertility, and uterine hemorrhage in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | 5 | 11 | 18 | 35 |
| Septic shock | D012772 | A48.3 | — | 4 | 8 | 6 | 10 | 27 | |
| Anesthesia | D000758 | — | — | 2 | 3 | 3 | 8 | ||
| Spinal anesthesia | D000775 | — | 1 | — | 5 | 1 | 7 | ||
| Blood pressure | D001794 | EFO_0004325 | 1 | — | — | 2 | 4 | 7 | |
| Sepsis | D018805 | A41.9 | — | 1 | 2 | 2 | 3 | 7 | |
| Shock | D012769 | R57.1 | — | — | 2 | 3 | 1 | 6 | |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | 1 | 2 | 5 |
| Hepatorenal syndrome | D006530 | K76.7 | 1 | — | 1 | 1 | 2 | 5 | |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | 2 | 4 |
| Vasoplegia | D056987 | — | — | 2 | — | 1 | 3 | ||
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | 2 | — | — | 2 |
| Fluid therapy | D005440 | — | — | 1 | — | — | 1 | ||
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | — | 1 | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | 1 | |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | 1 | — | — | 1 |
| Brain ischemia | D002545 | I67.82 | — | — | 1 | — | — | 1 | |
| Biliary atresia | D001656 | EFO_0004217 | Q44.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | 5 | 6 |
| Traumatic brain injuries | D000070642 | S06 | — | 1 | — | — | 2 | 3 | |
| Radiodermatitis | D011855 | L58 | 3 | 1 | — | — | — | 3 | |
| Ischemic stroke | D000083242 | 1 | 1 | — | — | — | 2 | ||
| Orthostatic hypotension | D007024 | I95.1 | 1 | 1 | — | — | — | 1 | |
| Depression | D003863 | F33.9 | — | 1 | — | — | — | 1 | |
| Suicidal ideation | D059020 | EFO_0004320 | R45.851 | — | 1 | — | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasoconstriction | D014661 | 2 | — | — | — | 5 | 7 | ||
| Vasodilation | D014664 | 2 | — | — | — | 2 | 4 | ||
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | 2 | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | — | — | 2 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | — | — | 1 | 3 |
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 1 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | 1 | — | — | — | — | 1 | ||
| Insulin resistance | D007333 | EFO_0002614 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carotid endarterectomy | D016894 | — | — | — | — | 3 | 3 | ||
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 2 | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | — | 1 | 1 | |
| Cardiopulmonary bypass | D002315 | — | — | — | — | 1 | 1 | ||
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | — | — | — | 1 | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 1 | 1 |
| Hyperthermic intraperitoneal chemotherapy | D000084262 | — | — | — | — | 1 | 1 | ||
| Gastrointestinal diseases | D005767 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NORETHYNODREL |
| INN | noretynodrel |
| Description | Norethynodrel is an oxo steroid. |
| Classification | Small molecule |
| Drug class | Progestogen; Progestin; Estrogen |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C |
Identifiers
| PDB | — |
| CAS-ID | 68-23-5 |
| RxCUI | 7515 |
| ChEMBL ID | CHEMBL1387 |
| ChEBI ID | 34895 |
| PubChem CID | 6231 |
| DrugBank | DB09371 |
| UNII ID | 88181ACA0M (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 560 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,920 adverse events reported
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