Nonoxynol 9
Delfen, Today (nonoxynol 9) is a small molecule pharmaceutical. Nonoxynol 9 was first approved as Delfen on 1982-01-01.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vcf contraceptive pre-filled applicators | OTC monograph not final | 2023-01-17 |
Indications
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Agency Specific
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Clinical
Clinical Trials
300 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dyslipidemias | D050171 | HP_0003119 | 6 | 3 | 5 | 10 | 3 | 27 | |
| Hypercholesterolemia | D006937 | HP_0003124 | 3 | 2 | 14 | 3 | 2 | 24 | |
| Healthy volunteers/patients | — | 9 | 1 | — | 1 | 8 | 19 | ||
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | 1 | 4 | 5 | 6 | 16 |
| Coronary disease | D003327 | — | 1 | 6 | 3 | 2 | 12 | ||
| Coronary artery disease | D003324 | I25.1 | — | 1 | 2 | 5 | 4 | 12 | |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | 1 | — | 5 | 2 | 3 | 11 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 2 | 3 | 1 | 2 | 10 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 2 | — | 1 | 3 | 7 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | 1 | — | 4 | 1 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 8 | — | 5 | 15 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 6 | — | 3 | 10 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | 4 | — | 1 | 6 |
| Neoplasms | D009369 | C80 | 3 | 4 | 1 | — | — | 6 | |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 2 | — | 2 | 4 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 1 | 2 | 1 | — | — | 4 |
| Flushing | D005483 | R23.2 | — | 1 | 1 | — | 1 | 3 | |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 2 | — | 1 | 3 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | 1 | — | 1 | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | 3 | — | — | 3 | 6 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | — | — | 3 | 5 |
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | 3 | — | — | — | 5 |
| Mitochondrial myopathies | D017240 | Orphanet_206966 | G71.3 | — | 1 | — | — | 3 | 4 |
| Cognitive dysfunction | D060825 | G31.84 | 1 | 1 | — | — | 2 | 4 | |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | 2 | 2 | — | — | — | 3 |
| Inflammation | D007249 | 1 | 1 | — | — | 2 | 3 | ||
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 2 | — | — | 1 | 3 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | 1 | — | — | — | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | C85.9 | 3 | — | — | — | — | 3 | |
| Multiple myeloma | D009101 | C90.0 | 1 | — | — | — | — | 1 | |
| Follicular lymphoma | D008224 | C82 | 1 | — | — | — | — | 1 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 1 | — | — | — | — | 1 | |
| Waldenstrom macroglobulinemia | D008258 | C88.0 | 1 | — | — | — | — | 1 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | — | — | — | — | 1 | |
| Hodgkin disease | D006689 | C81 | 1 | — | — | — | — | 1 | |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Melanosis | D008548 | EFO_0003963 | L81.1 | 1 | — | — | — | — | 1 |
| Actinic keratosis | D055623 | L57.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 6 | 6 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | — | — | — | 2 | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 1 | 1 |
| Sleep initiation and maintenance disorders | D007319 | F51.01 | — | — | — | — | 1 | 1 | |
| Respiratory sounds | D012135 | HP_0010307 | R06.1 | — | — | — | — | 1 | 1 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | — | — | — | 1 | 1 |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | — | — | — | 1 | 1 |
| Sleep deprivation | D012892 | F51.12 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NONOXYNOL 9 |
| INN | nonoxinol |
| Description | Tergitol NP-9 is a tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4. It has a role as a nonionic surfactant and a contraceptive drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 26571-11-9 |
| RxCUI | 53750 |
| ChEMBL ID | CHEMBL1410 |
| ChEBI ID | 53775 |
| PubChem CID | 72385 |
| DrugBank | DB06804 |
| UNII ID | K7O76887AP (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Safety
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Adverse Events
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35,891 adverse events reported
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