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Nitroprusside
Nipride (nitroprusside) is a small molecule pharmaceutical. Nitroprusside was first approved as Nitropress on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Nipride (generic drugs available since 2016-12-08, discontinued: Nitropress)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium nitroprusside
Tradename
Company
Number
Date
Products
NIPRIDE RTU IN SODIUM CHLORIDE 0.9%Exela Pharma SciencesN-209387 RX2017-03-08
2 products, RLD, RS
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
nipride rtuNew Drug Application2018-07-20
sodium nitroprusside ANDA2023-02-16
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C02: Antihypertensives
C02D: Arteriolar smooth muscle, agents acting on
C02DD: Nitroferricyanide derivatives acting on arteriolar smooth muscle
C02DD01: Nitroprusside
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I1011226
Intracranial vasospasmD020301EFO_1000994G45.9112
Coronary artery diseaseD003324I25.1112
Ischemic strokeD00008324211
Acute coronary syndromeD054058EFO_000567211
Spinal stenosisD013130EFO_0007490M48.011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cerebral hemorrhageD0025431124
Pre-eclampsiaD011225EFO_0000668O1422
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.91113
Subarachnoid hemorrhageD013345EFO_0000713I60112
Thoracic aortic aneurysmD017545EFO_000428211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug-related side effects and adverse reactionsD064420T88.711
Brain neoplasmsD001932EFO_0003833C7111
PainD010146EFO_0003843R5211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intracranial hemorrhagesD020300EFO_0000551I6211
Intratracheal intubationD00744211
Healthy volunteers/patients11
Cardiopulmonary bypassD00231511
Coronary artery bypassD001026EFO_000377611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNITROPRUSSIDE
INN
Description
Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. This may be done if the blood pressure is very high and resulting in symptoms, in certain types of heart failure, and during surgery to decrease bleeding. It is used by continuous injection into a vein. Onset is typically immediate and effects last for up to ten minutes.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O.O.[C]#N.[C]#N.[C]#N.[C]#N.[C]#N.[Fe-].[N-]=O.[Na+].[Na+]
Identifiers
PDB
CAS-ID13755-38-9
RxCUI
ChEMBL IDCHEMBL2097081
ChEBI ID7596
PubChem CID11953895
DrugBankDB00325
UNII ID
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,432 documents
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Safety
Black-box Warning
Black-box warning for: Nipride rtu, Sodium nitroprusside
Adverse Events
Top Adverse Reactions
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2,486 adverse events reported
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