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Netilmicin
Netromycin (netilmicin) is a small molecule pharmaceutical. Netilmicin was first approved as Netromycin on 1983-02-28. It is used to treat bacterial infections, gram-negative bacterial infections, and staphylococcal infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Netilmicin sulfate
Tradename
Company
Number
Date
Products
NETROMYCINMerck Sharp & DohmeN-050544 DISCN1983-02-28
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infectionsD001424A49
gram-negative bacterial infectionsD016905
staphylococcal infectionsD013203A49.01
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01G: Aminoglycoside antibacterials
J01GB: Other aminoglycosides in atc
J01GB07: Netilmicin
S: Sensory organ drugs
S01: Ophthalmologicals
S01A: Antiinfective ophthalmologics
S01AA: Antibiotics, ophthalmologic
S01AA23: Netilmicin
HCPCS
No data
Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ventilator-associated pneumoniaD053717EFO_1001865J95.851281110
InfectionsD007239EFO_00005444116
Cystic fibrosisD003550EFO_0000390E841124
Colorectal neoplasmsD01517911114
Dental pulp necrosisD003790K04.1314
Acinetobacter infectionsD000151EFO_1000792123
Bacterial infectionsD001424A491113
Critical illnessD016638112
Communicable diseasesD003141112
Gram-negative bacterial infectionsD01690522
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
BacteremiaD016470EFO_0003033R78.811213
PneumoniaD011014EFO_0003106J18213
Healthy volunteers/patients33
SepsisD018805A41.9112
Iatrogenic diseaseD00704911
Drug-related side effects and adverse reactionsD064420T88.711
BronchitisD001991J4011
PyelonephritisD011704EFO_1001141N10-N1611
Healthcare-associated pneumoniaD00007729911
Bacterial pneumoniaD018410EFO_1001272J15.911
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Crohn diseaseD003424EFO_0000384K5022
Heart failureD006333EFO_0003144I50112
Pseudomonas aeruginosaD011550NCBITaxon_28711
Weight lossD015431HP_000182411
CachexiaD002100HP_0004326R6411
AnorexiaD000855HP_0002039R63.011
Rectal neoplasmsD01200411
Anastomotic leakD05786811
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Inflammatory bowel diseasesD015212EFO_0003767112
Hepatic encephalopathyD006501K72.91112
Surgical wound infectionD013530112
Gram-negative bacteriaD00609011
RetinoblastomaD01217511
ObesityD009765EFO_0001073E66.911
NeoplasmsD009369C8011
Asymptomatic diseasesD05807011
DiverticulitisD004238EFO_1001460K5711
RegenerationD01203811
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ulcerative colitisD003093EFO_0000729K5111
Corneal diseasesD003316H18.911
Gestational diabetesD016640HP_0009800O24.411
Necrotizing enterocolitisD020345EFO_0003928K55.311
Hirschsprung diseaseD006627Q43.111
ColostomyD00312511
Meconium ileusD000074270P76.011
Liver cirrhosisD008103EFO_0001422K74.011
Portal hypertensionD006975EFO_0000666K76.611
Postoperative complicationsD01118311
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNETILMICIN
INNnetilmicin
Description
Netilmicin (1-N-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by Micromonospora inyoensis. Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.
Classification
Small molecule
Drug classantibiotics (Micromonospora strains)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O
Identifiers
PDB
CAS-ID56391-56-1
RxCUI7337
ChEMBL IDCHEMBL1572
ChEBI ID
PubChem CID441306
DrugBankDB00955
UNII ID4O5J85GJJB (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,636 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,681 adverse events reported
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