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Morphine
Duramorph, Embeda, Infumorph, Ms Contin (morphine) is a small molecule pharmaceutical. Morphine was first approved as Duramorph pf on 1984-09-18. It is used to treat dyspnea and intractable pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target delta-type opioid receptor and kappa-type opioid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Duramorph, Infumorph, Ms contin (generic drugs available since 1988-05-11, discontinued: Arymo, Astramorph, Avinza, Depodur, Kadian, Morphabond, Oramorph)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Morphine sulfate
Tradename
Company
Number
Date
Products
MORPHINE SULFATEFresenius KabiN-204223 RX2013-10-30
5 products, RLD, RS
INFUMORPHHikma PharmaceuticalsN-018565 RX1991-07-19
2 products, RLD, RS
DURAMORPH PFHikma PharmaceuticalsN-018565 RX1984-09-18
2 products, RLD, RS
MORPHINE SULFATEHikma PharmaceuticalsN-022195 RX2008-03-17
3 products, RLD
MORPHINE SULFATEHikma PharmaceuticalsN-022207 RX2008-03-17
2 products, RLD, RS
MORPHINE SULFATEHospiraN-202515 RX2011-11-14
5 products, RLD
MS CONTINPurdue PharmaN-019516 RX1987-05-29
5 products, RLD
Show 12 discontinued
Morphine sulfate
+
Naltrexone hydrochloride
Tradename
Company
Number
Date
Products
EMBEDAAlpharmaN-022321 DISCN2009-08-13
6 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
avinzaNew Drug Application2011-09-22
duramorphNew Drug Application2020-01-28
embedaNew Drug Application2010-01-22
infumorph 200 infumorph 500New Drug Application2020-01-28
kadianNew Drug Application2021-03-04
mitigoANDA2021-04-20
morphine sulfateANDA2023-06-12
ms continNew Drug Application2021-03-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dyspneaHP_0002094D004417R06.0
intractable painD010148
Agency Specific
FDA
EMA
Expiration
Code
MORPHINE SULFATE, MORPHINE SULFATE, HIKMA
2024-06-02NPP
Patent Expiration
Patent
Expires
Flag
FDA Information
Morphine Sulfate, Morphine Sulfate, Fresenius Kabi Usa
90727812034-03-12DP
91926082034-03-12U-43, U-55
92482292034-03-12DP
Morphine Sulfate, Arymo Er, Zyla
90444022033-07-01DPU-1556
95498992033-07-01DPU-1556
Morphine Sulfate / Naltrexone Hydrochloride, Embeda, Alpharma Pharms
86234182029-11-07U-1640
78159342027-12-12DP
76826332027-06-19U-1510
76826342027-06-19DP
81581562027-06-19U-1510
88461042027-06-19DP
88772472027-06-19DP
86854432025-07-03U-1508
86854442025-07-03DP
Morphine Sulfate, Morphabond Er, Daiichi Sankyo Inc
79556192028-08-12DP
103147882028-08-12DP
ATC Codes
A: Alimentary tract and metabolism drugs
A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
A07D: Antipropulsives
A07DA: Antipropulsives
A07DA52: Morphine, combinations
N: Nervous system drugs
N02: Analgesics
N02A: Opioid analgesics
N02AA: Natural opium alkaloid analgesics
N02AA01: Morphine
N02AA51: Morphine, combinations
N02AG: Opioids in combination with antispasmodics
N02AG01: Morphine and antispasmodics
R: Respiratory system drugs
R05: Cough and cold preparations
R05D: Cough suppressants, excl. combinations with expectorants
R05DA: Opium alkaloids and derivatives, cough suppressants
R05DA05: Opium alkaloids with morphine
HCPCS
Code
Description
J0364
Injection, apomorphine hydrochloride, 1 mg
J2270
Injection, morphine sulfate, up to 10 mg
J2274
Injection, morphine sulfate, preservative-free for epidural or intrathecal use, 10 mg
S0093
Injection, morphine sulfate, 500 mg (loading dose for infusion pump)
Clinical
Clinical Trials
874 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149G89.18320316253160
PainD010146EFO_0003843R52625293327112
AnalgesiaD00069812282942
Acute painD059787R52510912941
NeoplasmsD009369C8049122531
Chronic painD059350HP_001253236311425
AnesthesiaD00075821231219
Opioid-related disordersD009293EFO_0005611F11873218
Healthy volunteers/patients1332117
Replacement arthroplasty kneeD01964517816
Show 139 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501156
LymphomaD008223C85.9213
EmergenciesD00463033
Obstructive sleep apneaD020181EFO_0003918G47.331113
Wounds and injuriesD014947T14.8213
Inferior wall myocardial infarctionD056989EFO_1000983112
Shoulder painD020069HP_0030834M25.51112
LeukemiaD007938C95112
Myelodysplastic syndromesD009190D46112
Myeloproliferative disordersD009196D47.1112
Show 21 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.91134
Major depressive disorderD003865EFO_0003761F221123
Inflammatory bowel diseasesD015212EFO_00037671112
DiverticulitisD004238EFO_1001460K571112
Treatment-resistant depressive disorderD061218112
Heroin dependenceD006556EFO_0004240111
Referred painD05359111
Rotator cuff injuriesD000070636M75.111
Infratentorial neoplasmsD015192C71.711
Rheumatic diseasesD012216M79.0111
Show 16 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A123
Physiological stressD01331211
VasoplegiaD05698711
Type 2 diabetes mellitusD003924EFO_0001360E1111
Heart arrestD006323EFO_0009492I4611
Gastric emptyingD00574611
Fatty liverD00523411
Restless legs syndromeD012148EFO_0004270G25.8111
Traumatic brain injuriesD000070642S0611
Alzheimer diseaseD000544EFO_0000249F0311
Show 2 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HepatectomyD00649855
Postoperative complicationsD01118333
InflammationD00724922
Liver neoplasmsD008113EFO_1001513C22.022
Conduction anesthesiaD00076522
SchizophreniaD012559EFO_0000692F2022
Atrial fibrillationD001281EFO_0000275I48.022
Urinary retentionD016055HP_0000016R3311
ThoracotomyD01390811
Spine osteoarthritisD055013EFO_100078711
Show 66 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMORPHINE
INN
Description
Morphine is a morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). It has a role as an opioid analgesic, a mu-opioid receptor agonist, a plant metabolite, an environmental contaminant, a xenobiotic, a vasodilator agent, an anaesthetic, a drug allergen and a geroprotector. It is an organic heteropentacyclic compound, a tertiary amino compound and a morphinane alkaloid. It is a conjugate base of a morphine(1+). It derives from a hydride of a morphinan.
Classification
Small molecule
Drug classopioid
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
Identifiers
PDB1Q0Y
CAS-ID57-27-2
RxCUI7052
ChEMBL IDCHEMBL70
ChEBI ID17303
PubChem CID5288826
DrugBankDB00295
UNII ID
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
OPRD1
OPRD1
OPRK1
OPRK1
Organism
Homo sapiens
Gene name
OPRD1
Gene synonyms
OPRD
NCBI Gene ID
Protein name
delta-type opioid receptor
Protein synonyms
D-OR-1, delta opioid receptor 1, DOR-1
Uniprot ID
Mouse ortholog
Oprd1 (18386)
delta-type opioid receptor (P32300)
Variants
Clinical Variant
No data
Financial
Arymo - Zyla Life Sciences
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 100,210 documents
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Safety
Black-box Warning
Black-box warning for: Avinza, Duramorph, Embeda, Infumorph 200 infumorph 500, Kadian, Mitigo, Morphine sulfate, Ms contin
Adverse Events
Top Adverse Reactions
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138 adverse events reported
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