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Mipomersen
Kynamro (mipomersen) is an oligonucleotide pharmaceutical. Mipomersen was first approved as Kynamro on 2013-01-29. It is used to treat familial combined hyperlipidemia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mipomersen sodium
Tradename
Company
Number
Date
Products
KYNAMROKastle TherapeuticsN-203568 DISCN2013-01-29
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
kynamroNew Drug Application2017-01-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
familial combined hyperlipidemiaEFO_0000492D006950E78.49
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Mipomersen Sodium, Kynamro, Kastle Theraps Llc
75111312027-01-29DP
71019932023-09-05DP
70153152023-03-21DP
ATC Codes
C: Cardiovascular system drugs
C10: Lipid modifying agents
C10A: Lipid modifying agents, plain
C10AX: Other lipid modifying agents in atc
C10AX11: Mipomersen
HCPCS
No data
Clinical
Clinical Trials
224 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acne vulgarisD000152EFO_0003894L703456119
SchizophreniaD012559EFO_0000692F20126211
RosaceaD012393L7124218
PeriodontitisD010518EFO_0000649K05.32316
Ischemic strokeD000083242121216
Psychotic disordersD011618F20.8122115
Bipolar disorderD001714EFO_0000289F30.92215
StrokeD020521EFO_0000712I63.921114
HypertensionD006973EFO_0000537I1012114
Chronic periodontitisD055113EFO_0006343K05.3134
Show 16 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.91124
PneumothoraxD011030J93.111314
Major depressive disorderD003865EFO_0003761F221113
Multiple sclerosisD009103EFO_0003885G35123
InflammationD0072492113
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21112
Rheumatoid arthritisD001172EFO_0000685M06.922
Periodontal diseasesD010510K05.6112
Spinal cord injuriesD013119EFO_10019191112
Peri-implantitisD057873EFO_100139022
Show 12 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fragile x syndromeD005600Q99.21124
AsthmaD001249EFO_0000270J4533
Macular edemaD0082692213
AlcoholismD000437EFO_0003829F10.1313
Cognitive dysfunctionD060825G31.84213
Cerebral hemorrhageD002543323
Hiv infectionsD015658EFO_0000764B201213
Meibomian gland dysfunctionD000080343H02.88112
Retinal vein occlusionD012170EFO_1001157H34.81222
Relapsing-remitting multiple sclerosisD020529EFO_000392922
Show 47 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients6410
Autism spectrum disorderD000067877F84.022
Acute kidney injuryD058186HP_0001919N17112
AneurysmD000783HP_0002617I72.911
Arteriovenous malformationsD00116511
Periapical periodontitisD010485EFO_1001391K04.511
Substance-related disordersD019966EFO_0003890F1311
SyndromeD01357711
Alcohol-related disordersD019973F1011
Chemically-induced disordersD06441911
Show 8 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8011
Gram-negative bacterial infectionsD01690511
PainD010146EFO_0003843R5211
Opioid-related disordersD009293EFO_0005611F1111
AffectD00033911
ObesityD009765EFO_0001073E66.911
Diabetic nephropathiesD003928EFO_000040111
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMIPOMERSEN
INNmipomersen
Description
Mipomersen (INN; trade name Kynamro) is a drug used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection. There is a serious risk of liver damage from this drug and it can only be prescribed in the context of a risk management plan.
Classification
Oligonucleotide
Drug classantisense oligonucleotides
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COCCO[C@H]1[C@@H](O)[C@H](COP(=O)(O)S[C@H]2[C@H](COP(=O)(O)S[C@H]3[C@H](COP(=O)(O)S[C@H]4[C@H](COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cnc7c(=O)[nH]c(N)nc76)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(=O)[nH]c6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(=O)[nH]c6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cnc7c(=O)[nH]c(N)nc76)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(=O)[nH]c6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cc(C)c(=O)[nH]c6=O)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cnc7c(=O)[nH]c(N)nc76)O[C@@H]5COP(=O)(O)S[C@H]5C[C@H](n6cnc7c(N)ncnc76)O[C@@H]5COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cc(C)c(=O)[nH]c6=O)O[C@@H]5COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cc(C)c(N)nc6=O)O[C@@H]5COP(=O)(O)S[C@H]5[C@@H](OCCOC)[C@H](n6cnc7c(=O)[nH]c(N)nc76)O[C@@H]5CO)O[C@H](n5cc(C)c(N)nc5=O)[C@H]4OCCOC)O[C@H](n4cnc5c(N)ncnc54)[C@H]3OCCOC)O[C@H](n3cc(C)c(N)nc3=O)[C@H]2OCCOC)O[C@@H]1n1cc(C)c(N)nc1=O
Identifiers
PDB
CAS-ID629167-92-6
RxCUI1367839
ChEMBL IDCHEMBL2219536
ChEBI ID
PubChem CID44564107
DrugBankDB05528
UNII ID9GJ8S4GU0M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,128 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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6,985 adverse events reported
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