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Minocycline
Amzeeq, Arestin, Minocin, Minolira, Solodyn, Ximino, Zilxi (minocycline) is a small molecule pharmaceutical. Minocycline was first approved as Minocin on 1982-01-01. It is used to treat acne vulgaris, anthrax, borrelia infections, chancroid, and cholera amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Amzeeq, Arestin, Minocin, Minolira, Solodyn, Ximino, Zilxi (generic drugs available since 1990-07-31)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Minocycline hydrochloride
Tradename
Company
Number
Date
Products
MINOCINBausch Health CompaniesN-050649 RX1990-05-31
2 products, RLD
SOLODYNBausch Health CompaniesN-050808 RX2009-07-23
5 products, RLD, RS
MINOLIRANovanN-209269 RX2017-05-08
2 products, RS
XIMINOJourney MedicalN-201922 RX2012-07-11
3 products
AMZEEQJourney MedicalN-212379 RX2019-10-18
1 products, RLD, RS
ZILXIJourney MedicalN-213690 RX2020-05-28
1 products, RLD, RS
ARESTINOrapharmaN-050781 RX2001-02-16
1 products, RLD, RS
MINOCINREMPEXN-050444 RX1982-01-01
1 products, RLD, RS
Show 6 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amzeeqNew Drug Application2023-01-25
arestinNew Drug Application2020-06-01
dynacinANDA2014-12-18
minocinNew Drug Application2021-03-18
minocycline hydrochlorideANDA2023-06-19
minolira extended releaseNew Drug Application2019-09-04
solodynNew Drug Application2017-09-12
ximinoNew Drug Application2021-01-18
zilxiNew Drug Application2022-09-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
anthrax—D000881A22
borrelia infectionsEFO_1000842D001899—
chancroid—D002602A57
cholera—D002771A00
escherichia coli infectionsEFO_1001318D004927B96.20
meningococcal infectionsEFO_0004249D008589A39
mycoplasma infections—D009175—
plagueEFO_0007481D010930A20
psittacosisEFO_0007410D009956A70
Show 4 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Minocycline Hydrochloride, Amzeeq, Journey
103986412037-09-08U-2647
108498472037-09-08U-2647
88651392030-10-01DPU-1631, U-2647
89455162030-10-01DP
89928962030-10-01DPU-1631, U-2647
96757002030-10-01DPU-1631, U-2647
100860802030-10-01U-2647
101372002030-10-01U-2647
102135122030-10-01DPU-1631, U-2647
102654042030-10-01DP
105178822030-10-01U-2647
108211872030-10-01U-2647
Minocycline Hydrochloride, Minolira, Epi Hlth
111035172036-04-07DP
Minocycline Hydrochloride, Solodyn, Bausch
91926152031-11-17DP
75413472027-04-02U-917
75443732027-04-02DP
79194832027-03-07U-124, U-1078
77907052025-06-24U-124, U-1078
82527762025-06-24U-124
82688042025-06-24U-124, U-1078
87226502025-06-24U-1078
Minocycline Hydrochloride, Minocin, Rempex
90848022031-05-12U-282
92781052031-05-12U-282
Minocycline Hydrochloride, Zilxi, Journey
103221862030-10-01U-1631
109461012030-10-01U-1631
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB23: Minocycline
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AF: Antiinfectives for treatment of acne
— D10AF07: Minocycline
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01A: Tetracycline antibiotics
— J01AA: Tetracyclines
— J01AA08: Minocycline
HCPCS
Code
Description
J2265
Injection, minocycline hydrochloride, 1 mg
Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pulmonary hypertensionD006976EFO_0001361I27.20231117
Low cardiac outputD002303122116
Cardiogenic shockD012770R57.01——2—3
Septic shockD012772A48.3—1—1—2
CardiomyopathiesD009202EFO_0000318I421——1—2
Acute coronary syndromeD054058EFO_0005672———1—1
Pulmonary edemaD011654EFO_1001134J81———1—1
HemodynamicsD006439———1—1
AnesthesiaD000758———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiac surgical proceduresD006348——1——1
Mitral valve insufficiencyD008944HP_0001653——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I5043——16
Congenital heart defectsD006330HP_0001627Q24.9—3———3
Subarachnoid hemorrhageD013345EFO_0000713I60—1——12
Persistent fetal circulation syndromeD010547EFO_1001103P29.3—1——12
Intracranial vasospasmD020301EFO_1000994G45.9—1——12
Right ventricular dysfunctionD01849711———2
Cardio-renal syndromeD059347—1———1
Renal insufficiencyD051437HP_0000083N19—1———1
Heart transplantationD016027EFO_0010673—1———1
Myocardial reperfusion injuryD015428EFO_000268711———1
Show 6 more
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I95————11
Myocardial ischemiaD017202EFO_1001375I20-I25————11
Aortic valve stenosisD001024EFO_0000266Q25.1————11
Diastolic heart failureD054144EFO_1000899I50.30————11
Physiologic monitoringD008991————11
HepatectomyD006498————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMINOCYCLINE
INNminocycline
Description
Minocycline zwitterion is a zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of minocycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.). It is a zwitterion and an a tetracycline zwitterion. It is a conjugate acid of a minocycline(1-). It is a tautomer of a minocycline.
Classification
Small molecule
Drug classantibiotics (tetracycline derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)c1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O
Identifiers
PDB—
CAS-ID10118-90-8
RxCUI6980
ChEMBL IDCHEMBL1434
ChEBI ID50694
PubChem CID51537604
DrugBankDB01017
UNII IDFYY3R43WGO (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Amzeeq - Fortress Biotech, Inc.
$
€
£
₣
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Minolira - Novan
$
€
£
₣
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Minocin - MELINTA THERAPEUTICS, INC. /NEW/
$
€
£
₣
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Ximino - Fortress Biotech, Inc.
$
€
£
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Ximino - Journey Medical
$
€
£
₣
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Zilxi - Fortress Biotech, Inc.
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 28,293 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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545 adverse events reported
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