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Methocarbamol
Robaxin, Robaxisal (methocarbamol) is a small molecule pharmaceutical. Methocarbamol was first approved as Robaxisal on 1982-01-01. It is used to treat muscle cramp, muscle rigidity, myositis, pain, and spasm amongst others in the USA. It is known to target carbonic anhydrase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Robaxin (generic drugs available since 1982-01-01, discontinued: Delaxin, Forbaxin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Methocarbamol
Tradename
Company
Number
Date
Products
ROBAXISALA.H. Robins CompanyN-012281 DISCN1982-01-01
1 products, RLD
Hide discontinued
Methocarbamol
Tradename
Company
Number
Date
Products
ROBAXINHikma PharmaceuticalsN-011790 RX1982-01-01
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
methocarbamolANDA2023-06-07
robaxinNew Drug Application2018-12-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
muscle crampHP_0003394D009120
muscle rigidityHP_0002063D009127
myositisEFO_0000783D009220G72.49
painEFO_0003843D010146R52
spasmD013035M62.83
tetanusEFO_0005593D013742A35
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M03: Muscle relaxants
M03B: Muscle relaxants, centrally acting agents
M03BA: Carbamic acid esters, centrally acting muscle relaxants
M03BA03: Methocarbamol
M03BA53: Methocarbamol, combinations excl. psycholeptics
M03BA73: Methocarbamol, combinations with psycholeptics
HCPCS
Code
Description
J2800
Injection, methocarbamol, up to 10 ml
Clinical
Clinical Trials
22 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graves diseaseD006111EFO_0004237E05.0111439
Healthy volunteers/patients11
RecurrenceD01200811
TherapeuticsD01381211
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graves ophthalmopathyD049970EFO_100146611113
HyperthyroidismD006980E05.91113
AtherosclerosisD050197EFO_0003914I25.111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_0000515123
DermatomyositisD003882EFO_0000398M3311
PolymyositisD017285EFO_0003063M33.211
GliomaD005910EFO_000052011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanosisD008548EFO_0003963L81.111
GliosarcomaD01831611
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MicrobiotaD06430722
Gastrointestinal microbiomeD00006919611
Patient acceptance of health careD01034211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHOCARBAMOL
INNmethocarbamol
Description
2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate is a carbamate ester that is glycerol in which one of the primary alcohol groups has been converted to its 2-methoxyphenyl ether while the other has been converted to the corresponding carbamate ester. It is a carbamate ester, a secondary alcohol and an aromatic ether.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccccc1OCC(O)COC(N)=O
Identifiers
PDB
CAS-ID532-03-6
RxCUI6845
ChEMBL IDCHEMBL1201117
ChEBI ID77498
PubChem CID4107
DrugBankDB00423
UNII ID125OD7737X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA1
CA1
Organism
Homo sapiens
Gene name
CA1
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 1
Protein synonyms
CA-I, CAB, Carbonate dehydratase I, Carbonic anhydrase B, Carbonic anhydrase I, Cyanamide hydratase CA1, epididymis secretory protein Li 11, epididymis secretory sperm binding protein
Uniprot ID
Mouse ortholog
Car1 (12346)
carbonic anhydrase 1 (Q9DC84)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 716 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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2,223 adverse events reported
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