Skip to content
Methazolamide
Neptazane (methazolamide) is a small molecule pharmaceutical. Methazolamide was first approved as Neptazane on 1982-01-01. It is used to treat angle-closure glaucoma and open-angle glaucoma in the USA. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 12, carbonic anhydrase 1, carbonic anhydrase 14, and carbonic anhydrase 4.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methazolamide
Tradename
Company
Number
Date
Products
NEPTAZANELederle LaboratoriesN-011721 DISCN1982-01-01
2 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
methazolamideANDA2022-12-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angle-closure glaucoma—D015812—
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EC: Carbonic anhydrase inhibitors, antiglaucoma drugs and miotics
— S01EC05: Methazolamide
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameMETHAZOLAMIDE
INNmethazolamide
Description
Methazolamide is a member of thiadiazoles and a sulfonamide.
Classification
Small molecule
Drug classcarbonic anhydrase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)/N=c1/sc(S(N)(=O)=O)nn1C
Identifiers
PDB5KU6
CAS-ID554-57-4
RxCUI6826
ChEMBL IDCHEMBL19
ChEBI ID6822
PubChem CID4100
DrugBankDB00703
UNII IDW733B0S9SD (ChemIDplus, GSRS)
Target
Agency Approved
CA7
CA7
Organism
Homo sapiens
Gene name
CA7
Gene synonyms
NCBI Gene ID
766
Protein name
carbonic anhydrase 7
Protein synonyms
CA-VII, Carbonate dehydratase VII, Carbonic anhydrase VII, carbonic dehydratase VII
Uniprot ID
P43166
Mouse ortholog
Car7 (12354)
carbonic anhydrase 7 (Q9ERQ8)
Alternate
CA12
CA12
CA1
CA1
CA14
CA14
CA4
CA4
Organism
Homo sapiens
Gene name
CA12
Gene synonyms
NCBI Gene ID
771
Protein name
carbonic anhydrase 12
Protein synonyms
CA-XII, Carbonate dehydratase XII, Carbonic anhydrase XII, carbonic dehydratase, Tumor antigen HOM-RCC-3.1.3
Uniprot ID
Q9BWG2
Mouse ortholog
Car12 (76459)
carbonic anhydrase 12 (Q8CI85)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 922 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
2 adverse events reported
View more details