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Meperidine
Demerol, Mepergan (meperidine) is a small molecule pharmaceutical. Meperidine was first approved as Meperidine and atropine sulfate on 1982-01-01. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target kappa-type opioid receptor and delta-type opioid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Demerol (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meperidine hydrochloride
Tradename
Company
Number
Date
Products
DEMEROLHospiraN-021171 RX1982-01-01
4 products, RLD, RS
Show 1 discontinued
Meperidine hydrochloride
+
Promethazine hydrochloride
Tradename
Company
Number
Date
Products
MEPERGANHikma PharmaceuticalsN-011730 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
demerolNew Drug Application2021-11-04
meperidine hydrochlorideANDA2022-09-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AB: Phenylpiperidine derivatives, opioid analgesics
— N02AB02: Pethidine
— N02AB52: Pethidine, combinations excl. psycholeptics
— N02AB72: Pethidine, combinations with psycholeptics
— N02AG: Opioids in combination with antispasmodics
— N02AG03: Pethidine and antispasmodics
HCPCS
Code
Description
J2175
Injection, meperidine hydrochloride, per 100 mg
J2180
Injection, meperidine and promethazine hcl, up to 50 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMEPERIDINE
INNpethidine
Description
Pethidine is a piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain. It has a role as an opioid analgesic, a kappa-opioid receptor agonist, a mu-opioid receptor agonist and an antispasmodic drug. It is an ethyl ester, a piperidinecarboxylate ester and a tertiary amino compound. It is a conjugate base of a pethidine(1+).
Classification
Small molecule
Drug classanalgesics (meperidine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C1(c2ccccc2)CCN(C)CC1
Identifiers
PDB—
CAS-ID57-42-1
RxCUI6754
ChEMBL IDCHEMBL607
ChEBI ID6754
PubChem CID4058
DrugBankDB00454
UNII ID9E338QE28F (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
OPRK1
OPRK1
OPRD1
OPRD1
Organism
Homo sapiens
Gene name
OPRK1
Gene synonyms
OPRK
NCBI Gene ID
4986
Protein name
kappa-type opioid receptor
Protein synonyms
kappa opioid receptor, Opiate receptor, kappa-1
Uniprot ID
Q499G4
Mouse ortholog
Oprk1 (18387)
kappa-type opioid receptor (P33534)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 15,043 documents
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Safety
Black-box Warning
Black-box warning for: Demerol, Meperidine hydrochloride
Adverse Events
Top Adverse Reactions
Mock data
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7 adverse events reported
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