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Mepenzolate
Cantil (mepenzolate) is a small molecule pharmaceutical. Mepenzolate was first approved as Cantil on 1982-01-01. It is used to treat peptic ulcer in the USA. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M3, and muscarinic acetylcholine receptor M4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mepenzolate bromide
Tradename
Company
Number
Date
Products
CANTILSanofiN-010679 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
peptic ulcerHP_0004398D010437K27
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A03: Drugs for functional gastrointestinal disorders
A03A: Drugs for functional gastrointestinal disorders
A03AB: Synthetic anticholinergics, quaternary ammonium compounds for functional gastrointestinal disorders
A03AB12: Mepenzolate
HCPCS
No data
Clinical
Clinical Trials
269 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52108101533
NeuralgiaD009437EFO_00094301622717
Healthy volunteers/patients631716
Diabetic neuropathiesD003929EFO_1000783156211
Postherpetic neuralgiaD0514741235
Knee osteoarthritisD020370EFO_0004616M172114
Peripheral nerve injuriesD0593481123
ExerciseD015444EFO_0000483123
Central nervous system sensitizationD059333112
Motor disordersD00006807911
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral nervous system diseasesD010523G6455211
CoughD003371HP_0012735R0542149
Hiv infectionsD015658EFO_0000764B20437
Herpes zosterD006562EFO_0006510B02526
Breast neoplasmsD001943EFO_0003869C501124
Acute painD059787R521124
Head and neck neoplasmsD006258112
PharyngitisD010612R07.022
Stomach neoplasmsD013274EFO_0003897C1622
VulvodyniaD056650N94.81111
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Deglutition disordersD003680HP_0002015R13.1257
PruritusD011537HP_0000989L291156
Parkinson diseaseD010300EFO_0002508G202113
VomitingD014839HP_0002013R11.1213
Facial painD005157R51.9112
Pulmonary hypertensionD006976EFO_0001361I27.2022
Myofascial pain syndromesD009209EFO_1001054112
Diabetes mellitusD003920EFO_0000400E08-E1322
PolyneuropathiesD011115EFO_0009562A69.2222
Colonic neoplasmsD003110C18112
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tobacco use disorderD014029F17268
Tobacco useD064424Z72.0145
Migraine disordersD008881EFO_0003821G43224
StrokeD020521EFO_0000712I63.9134
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21213
MetabolismD008660GO_000815222
Sickle cell anemiaD000755EFO_0000697D5711
Cluster headacheD003027HP_0012199G44.0011
Trigeminal autonomic cephalalgiasD05130311
Paroxysmal hemicraniaD051302EFO_1001822G44.0311
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dental cariesD003731EFO_0003819K021010
VapingD00007213799
SmokingD012907EFO_0003768F1766
ThirstD01389444
HyperalgesiaD00693033
Tobacco smokingD00007386933
HeadacheD006261HP_0002315R5122
ArthritisD001168EFO_0005856M05-M1422
Irritable bowel syndromeD043183EFO_0000555K5822
Chest painD002637HP_0100749R07.922
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMEPENZOLATE
INNmepenzolate bromide
Description
2-hydroxy-2,2-diphenylacetic acid (1,1-dimethyl-3-piperidin-1-iumyl) ester is a diarylmethane.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1
Identifiers
PDB
CAS-ID25990-43-6
RxCUI107770
ChEMBL IDCHEMBL524004
ChEBI ID
PubChem CID4057
DrugBankDB04843
UNII IDAPX8D32IX1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM3
CHRM3
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 132 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,691 adverse events reported
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