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Mefloquine
Lariam (mefloquine) is a small molecule pharmaceutical. Mefloquine was first approved as Lariam on 1989-05-02. It is used to treat falciparum malaria, malaria, and vivax malaria in the USA. It is known to target adenosine receptor A1 and adenosine receptor A2a.
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COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mefloquine hydrochloride
Tradename
Company
Number
Date
Products
LARIAMRocheN-019591 DISCN1989-05-02
1 products, RLD
MEFLOQUINE HYDROCHLORIDEUS ARMY WALTER REEDN-019578 DISCN1989-05-02
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
mefloquine hydrochlorideANDA2023-02-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
falciparum malariaEFO_0007444D016778B50
malariaEFO_0001068D008288B54
vivax malariaEFO_0007445D016780B51
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01B: Antimalarials
— P01BC: Methanolquinolines, antimalarial
— P01BC02: Mefloquine
— P01BF: Artemisinin and derivatives, combinations
— P01BF02: Artesunate and mefloquine
HCPCS
No data
Clinical
Clinical Trials
54 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B5426106526
Falciparum malariaD016778EFO_0007444B501593620
Healthy volunteers/patients—1——1—2
Parasitic diseasesD010272EFO_0001067B88———1—1
Vivax malariaD016780EFO_0007445B51———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20——1—34
PregnancyD011247EFO_0002950Z33.1—11—12
Schistosoma haematobiumD012548——1——1
Schistosoma mansoniD012550NCBITaxon_6183——1——1
Respiratory insufficiencyD012131HP_0002093J96.9—11——1
Viral pneumoniaD011024EFO_0007541J12.9—11——1
Covid-19D000086382U07.1—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sickle cell anemiaD000755EFO_0000697D5711———1
Schistosomiasis haematobiaD012553EFO_0007530B65.0—1———1
Progressive multifocal leukoencephalopathyD007968EFO_0007455A81.211———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_00005151————1
GliosarcomaD0183161————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug resistanceD004351Z16.30————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMEFLOQUINE
INNmefloquine
Description
(-)-(11S,2'R)-erythro-mefloquine is an optically active form of [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol having (-)-(11S,2'R)-erythro-configuration. An antimalarial agent, used in racemic form, which acts as a blood schizonticide; its mechanism of action is unknown. It has a role as an antimalarial. It is an enantiomer of a (+)-(11R,2'S)-erythro-mefloquine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OC(c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)C1CCCCN1
Identifiers
PDB—
CAS-ID49752-90-1
RxCUI—
ChEMBL IDCHEMBL416956
ChEBI ID63681
PubChem CID40692
DrugBankDB00358
UNII IDTML814419R (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADORA1
ADORA1
ADORA2A
ADORA2A
Organism
Homo sapiens
Gene name
ADORA1
Gene synonyms
NCBI Gene ID
134
Protein name
adenosine receptor A1
Protein synonyms
Uniprot ID
Q8TAM8
Mouse ortholog
Adora1 (11539)
adenosine receptor A1 (Q9WUF9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,192 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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