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Mannitol 20%, Bronchitol(mannitol)
Aridol, Bronchitol, Osmitrol (mannitol) is a small molecule pharmaceutical. Mannitol was first approved as Mannitol 20% on 1982-01-01. It is used to treat anuria, brain edema, ocular hypertension, and oliguria in the USA. It has been approved in Europe to treat cystic fibrosis.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
respiratory tract diseasesD012140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Aridol, Bronchitol, Osmitrol (generic drugs available since 1982-01-01, discontinued: Resectisol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mannitol
Tradename
Company
Number
Date
Products
MANNITOL 5% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 10% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 15% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
MANNITOL 20% IN PLASTIC CONTAINERB. Braun MedicalN-020006 RX1993-07-26
1 products
OSMITROL 5% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 10% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 20% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 15% IN WATERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 5% IN WATER IN PLASTIC CONTAINERBaxterN-013684 RX1982-01-01
1 products
OSMITROL 10% IN WATER IN PLASTIC CONTAINERBaxterN-013684 RX1982-01-01
1 products
Show 6 marketed
Show 22 discontinued
Mannitol
+
Sorbitol
Tradename
Company
Number
Date
Products
SORBITOL-MANNITOL IN PLASTIC CONTAINERICU MedicalN-018316 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
aridol bronchial challenge test kitNew Drug Application2020-09-02
bronchitolNew Drug Application2020-11-10
osmitrolNew Drug Application2018-11-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anuriaEFO_0009530D001002R34
brain edemaEFO_1000845D001929G93.6
ocular hypertensionEFO_1001069D009798H40.0
oliguriaD009846
Agency Specific
FDA
EMA
Expiration
Code
MANNITOL, BRONCHITOL, CHIESI
2027-10-30ODE-327
2023-10-30NP
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A06: Drugs for constipation
A06A: Drugs for constipation
A06AD: Osmotically acting laxatives
A06AD16: Mannitol
B: Blood and blood forming organ drugs
B05: Blood substitutes and perfusion solutions
B05B: Iv solutions used in parenteral administration of fluids, electrolytes and nutrients
B05BC: Solutions producing osmotic diuresis
B05BC01: Mannitol
B05C: Irrigating solutions, blood substitutes and perfusion
B05CX: Other irrigating solutions in atc
B05CX04: Mannitol
R: Respiratory system drugs
R05: Cough and cold preparations
R05C: Expectorants, excl. combinations with cough suppressants
R05CB: Mucolytics
R05CB16: Mannitol
V: Various drug classes in atc
V04: Diagnostic agents
V04C: Other diagnostic agents in atc
V04CX: Other diagnostic agents in atc
V04CX04: Mannitol
HCPCS
Code
Description
J2150
Injection, mannitol, 25% in 50 ml
J7665
Mannitol, administered through an inhaler, 5 mg
Clinical
Clinical Trials
146 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J45222814
Intracranial hypertensionD019586EFO_10009921132410
Traumatic brain injuriesD000070642S06123127
Brain edemaD001929EFO_1000845G93.612215
AnesthesiaD000758112
Intracranial pressureD007427112
HeadacheD006261HP_0002315R5111
ConstipationD003248HP_0002019K59.011
Diabetic retinopathyD003930EFO_000377011
InflammationD00724911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cystic fibrosisD003550EFO_0000390E8425310
BronchiectasisD001987HP_0002110J472224
Covid-19D000086382U07.1212
Kidney neoplasmsD007680EFO_0003865C64112
Drug-related side effects and adverse reactionsD064420T88.71112
PulpitisD011671EFO_1001139K04.0111
Respiratory soundsD012135HP_0010307R06.111
Congenital heart defectsD006330HP_0001627Q24.911
NeuroprotectionD00006682911
Newborn infant diseasesD00723211
Show 14 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain neoplasmsD001932EFO_0003833C711246
Healthy volunteers/patients515
GlioblastomaD005909EFO_00005151213
Obstructive lung diseasesD008173HP_0006536112
GliomaD005910EFO_0000520122
AstrocytomaD001254EFO_0000271122
PneumoniaD011014EFO_0003106J18112
StrokeD020521EFO_0000712I63.922
Craniocerebral traumaD006259S00222
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9222
Show 15 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52112
Central nervous system neoplasmsD01654322
PharmacokineticsD01059911
BurnsD002056T30.011
HypersensitivityD006967EFO_0003785T78.4011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute liver failureD01711433
CoughD003371HP_0012735R0533
Supratentorial neoplasmsD015173C71.033
Chronic kidney failureD007676EFO_0003884N18.622
WheelchairsD01491011
Dietary supplementsD01958711
ObesityD009765EFO_0001073E66.911
Body weightD001835EFO_000433811
Metabolic syndromeD024821EFO_0000195E88.8111
Nutrition disordersD009748EFO_000106911
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMANNITOL
INN
Description
D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Identifiers
PDB
CAS-ID69-65-8
RxCUI6628
ChEMBL IDCHEMBL689
ChEBI ID16899
PubChem CID6251
DrugBankDB00742
UNII ID
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 76,660 documents
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Safety
Black-box Warning
Black-box warning for: Aridol bronchial challenge test kit
Adverse Events
Top Adverse Reactions
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31,601 adverse events reported
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