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Lithium
Lithobid, Lithonate (lithium) is a small molecule pharmaceutical. Lithium was first approved as Lithobid on 1982-01-01. It is used to treat bipolar disorder, conduct disorder, depressive disorder, and post-traumatic stress disorders in the USA. The pharmaceutical is active against inositol monophosphatase 1. In addition, it is known to target glycogen synthase kinase-3 beta.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Lithobid (generic drugs available since 1986-05-21, discontinued: Eskalith, Lithane, Lithonate, Lithotabs)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lithium carbonate
Tradename
Company
Number
Date
Products
LITHOBIDANI PHARMSN-018027 RX1982-01-01
1 products, RLD, RS
LITHIUM CARBONATEHikma PharmaceuticalsN-017812 RX1982-01-01
3 products, RLD
LITHIUM CARBONATEHikma PharmaceuticalsN-018558 RX1982-01-29
1 products, RLD, RS
Show 7 discontinued
Lithium citrate
Tradename
Company
Number
Date
Products
LITHIUM CITRATEHikma PharmaceuticalsN-018421 DISCN1982-01-01
1 products, RLD
LITHONATESolvay PharmaceuticalsN-017672 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
lithobidNew Drug Application2020-02-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bipolar disorderEFO_0000289D001714F30.9
conduct disorderEFO_0004216D019955F91
depressive disorderEFO_1002014D003866F32.A
post-traumatic stress disordersEFO_0001358D013313F43.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
D11: Other dermatological preparations in atc
D11A: Other dermatological preparations in atc
D11AX: Other dermatological preparations in atc
D11AX04: Lithium succinate
N: Nervous system drugs
N05: Psycholeptics
N05A: Antipsychotics
N05AN: Lithium antipsychotics
N05AN01: Lithium
HCPCS
Code
Description
A4235
Replacement battery, lithium, for use with medically necessary home blood glucose monitor owned by patient, each
A4601
Lithium ion battery, rechargeable, for non-prosthetic use, replacement
A4602
Replacement battery for external infusion pump owned by patient, lithium, 1.5 volt, each
E2397
Power wheelchair accessory, lithium-based battery, each
K0604
Replacement battery for external infusion pump owned by patient, lithium, 3.6 volt, each
K0605
Replacement battery for external infusion pump owned by patient, lithium, 4.5 volt, each
L7367
Lithium ion battery, rechargeable, replacement
L7368
Lithium ion battery charger, replacement only
L8623
Lithium ion battery for use with cochlear implant device speech processor, other than ear level, replacement, each
L8624
Lithium ion battery for use with cochlear implant or auditory osseointegrated device speech processor, ear level, replacement, each
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Clinical
Clinical Trials
98 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypothyroidismD007037EFO_0004705E03.941239
CataractD002386EFO_0001059H26.9235
DepressionD003863F33.91214
HyperlipidemiasD006949EFO_0003774E78.511
HypopituitarismD007018EFO_0001380E23.011
Papillary thyroid cancerD00007727311
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acne vulgarisD000152EFO_0003894L701124
Congenital heart defectsD006330HP_0001627Q24.9123
Bipolar disorderD001714EFO_0000289F30.922
Depressive disorderD003866EFO_1002014F32.A11
Postoperative cognitive complicationsD00007969011
ObesityD009765EFO_0001073E66.911
Autoimmune hypothyroidismC56276811
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients818
Thyroid neoplasmsD013964EFO_0003841235
Euthyroid sick syndromesD005067EFO_1000931E07.81224
Heart failureD006333EFO_0003144I503314
Breast neoplasmsD001943EFO_0003869C50123
Covid-19D000086382U07.1213
GlioblastomaD005909EFO_0000515112
Alzheimer diseaseD000544EFO_0000249F03122
Respiratory distress syndromeD012128EFO_1000637J80122
NeoplasmsD009369C801112
Show 13 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD006258112
AnalgesiaD00069811
AnesthesiaD00075811
Local anesthesiaD00077211
HelminthiasisD006373EFO_1001342B65-B8311
Allergic rhinitisD065631J30.911
Multiple sclerosisD009103EFO_0003885G3511
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Chronic progressive multiple sclerosisD02052811
Prostatic neoplasmsD011471C6111
Show 3 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Edentulous jawD00757533
Major depressive disorderD003865EFO_0003761F2222
AstigmatismD001251H52.222
Brain neoplasmsD001932EFO_0003833C7111
StrokeD020521EFO_0000712I63.911
Alveolar bone lossD01630111
AgingD000375GO_0007568R41.8111
Coronary diseaseD00332711
Tooth diseasesD01407611
Refractive errorsD012030EFO_0003908H52.711
Show 7 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLITHIUM
INN
Description
Lithium Citrate, Lithonate (lithium) is a small molecule pharmaceutical. Lithium was first approved as Lithium Citrate on 1982-01-01. It is used to treat in the USA. The pharmaceutical is active against inositol monophosphatase 1. In addition, it is known to target glycogen synthase kinase-3 beta.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
[LiH]
Identifiers
PDB
CAS-ID7439-93-2
RxCUI
ChEMBL IDCHEMBL2146126
ChEBI ID30146
PubChem CID
DrugBank
UNII ID
Target
Agency Approved
IMPA1
IMPA1
Organism
Homo sapiens
Gene name
IMPA1
Gene synonyms
IMPA
NCBI Gene ID
Protein name
inositol monophosphatase 1
Protein synonyms
D-galactose 1-phosphate phosphatase, IMP 1, IMPase 1, inositol(myo)-1(or 4)-monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1, myo-inositol monophosphatase 1, testicular tissue protein Li 94
Uniprot ID
Mouse ortholog
Impa1 (55980)
inositol monophosphatase 1 (O55023)
Alternate
GSK3B
GSK3B
Organism
Homo sapiens
Gene name
GSK3B
Gene synonyms
NCBI Gene ID
Protein name
glycogen synthase kinase-3 beta
Protein synonyms
GSK-3 beta, Serine/threonine-protein kinase GSK3B
Uniprot ID
Mouse ortholog
Gsk3b (56637)
glycogen synthase kinase-3 beta (Q9WV60)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 130,833 documents
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Safety
Black-box Warning
Black-box warning for: Lithobid
Adverse Events
Top Adverse Reactions
Mock data
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3,025 adverse events reported
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