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Levorphanol
Levo-dromoran (levorphanol) is a small molecule pharmaceutical. Levorphanol was first approved as Levo-dromoran on 1991-12-19. It is used to treat pain in the USA. The pharmaceutical is active against mu-type opioid receptor. In addition, it is known to target glutamate receptor ionotropic, NMDA 2C.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levorphanol tartrate
Tradename
Company
Number
Date
Products
LEVO-DROMORANBausch Health CompaniesN-008719 DISCN1991-12-19
1 products
LEVO-DROMORANBausch Health CompaniesN-008720 DISCN1991-12-19
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
levorphanol tartrateANDA2022-11-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code
Description
J1960
Injection, levorphanol tartrate, up to 2 mg
Clinical
Clinical Trials
59 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R521528
AnesthesiaD000758224
Hip osteoarthritisD015207EFO_1000786M161123
Postoperative painD010149G89.18213
PulpitisD011671EFO_1001139K04.0123
Local anesthesiaD0007721113
Knee osteoarthritisD020370EFO_0004616M171112
Nerve blockD009407112
Spinal anesthesiaD00077522
HypertensionD006973EFO_0000537I1022
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
RuptureD012421112
Wounds and injuriesD014947T14.811
EmergenciesD00463011
AnalgesiaD00069811
Vaginal dischargeD01952211
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.5111
Intervertebral disc degenerationD055959HP_0008419111
Ischemic strokeD00008324211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Compartment syndromesD003161T79.A011
Healthy volunteers/patients11
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I9511
Anterior cruciate ligament injuriesD00007059811
Orthodontic anchorage proceduresD05228011
BursitisD002062EFO_1000941M71.911
EdemaD004487R60.911
TrismusD01431311
Chronic renal insufficiencyD051436N1811
Neuromuscular blockadeD01914811
VibrationD01473211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEVORPHANOL
INNlevorphanol
Description
Levorphanol is a morphinane alkaloid.
Classification
Small molecule
Drug classnarcotic antagonists/agonists (morphinan derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13
Identifiers
PDB
CAS-ID77-07-6
RxCUI6378
ChEMBL IDCHEMBL592
ChEBI ID6444
PubChem CID5359272
DrugBankDB00854
UNII ID27618J1N2X (ChemIDplus, GSRS)
Target
Agency Approved
OPRM1
OPRM1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Alternate
GRIN2C
GRIN2C
Organism
Homo sapiens
Gene name
GRIN2C
Gene synonyms
NMDAR2C
NCBI Gene ID
Protein name
glutamate receptor ionotropic, NMDA 2C
Protein synonyms
GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), GluN2C(del_e2), GluN2C-b alternative isoform, Glutamate [NMDA] receptor subunit epsilon-3, glutamate receptor, ionotropic, N-methyl D-aspartate 2C, N-methyl D-aspartate receptor subtype 2C, N-methyl-D-aspartate receptor subunit 2C, NMDAR2C, NR2C, putative NMDtranscript(altAcc_e11), putative NMDtranscript(altDon_e4), putative NMDtranscript(del_e4)
Uniprot ID
Mouse ortholog
Grin2c (14813)
glutamate receptor ionotropic, NMDA 2C (Q01098)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 863 documents
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Safety
Black-box Warning
Black-box warning for: Levorphanol tartrate
Adverse Events
Top Adverse Reactions
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266 adverse events reported
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