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Levocabastine
Livostin (levocabastine) is a small molecule pharmaceutical. Levocabastine was first approved as Livostin on 1993-11-10. It is used to treat allergic conjunctivitis in the USA. It is known to target neurotensin receptor type 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levocabastine hydrochloride
Tradename
Company
Number
Date
Products
LIVOSTINNovartisN-020219 DISCN1993-11-10
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic conjunctivitisEFO_0007141D003233H10.44
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R01: Nasal preparations
R01A: Decongestants and other nasal preparations for topical use
R01AC: Antiallergic nasal preparations for topical use, excl. corticosteroids
R01AC02: Levocabastine
S: Sensory organ drugs
S01: Ophthalmologicals
S01G: Decongestants and antiallergics
S01GX: Other antiallergics in atc
S01GX02: Levocabastine
HCPCS
No data
Clinical
Clinical Trials
1635 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149G89.18257653137137405
PainD010146EFO_0003843R52513165139121
AnalgesiaD000698447142452
Replacement arthroplasty kneeD019645131251444
AnesthesiaD000758264141943
Spinal anesthesiaD00077514171941
Acute painD059787R5238621740
Local anesthesiaD00077235371936
Breast neoplasmsD001943EFO_0003869C502966930
Labor painD048949214101228
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Video-assisted thoracic surgeryD0207751135
Pancreatic neoplasmsD010190EFO_0003860C251124
Ventral herniaD006555EFO_1001866K431113
Spinal fusionD0131231113
Chronic pancreatitisD050500EFO_0000342K86.11113
Thoracic diseasesD0138961213
Abdominal painD015746R10.92113
Intraoperative complicationsD007431123
Coronary artery diseaseD003324I25.1123
Female genital neoplasmsD005833123
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HerniorrhaphyD059685134
Thyroid diseasesD013959HP_0000820E00-E07123
HerniaD006547HP_0100790K40-K46213
Postherpetic neuralgiaD0514741113
Myofascial pain syndromesD009209EFO_1001054112
PhimosisD010688EFO_1001104N47.1112
ParaphimosisD010263EFO_1001086N47.2112
BalanitisD001446EFO_1000833N48.1112
Ankle injuriesD016512S93.4112
Thyroid noduleD016606EFO_1001436112
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
Lung diseasesD008171EFO_0003818J98.4123
SternotomyD05634622
AdenomyosisD062788EFO_1001757N80.0112
Primary dysautonomiasD05496922
Emergence deliriumD000071257112
Post-dural puncture headacheD051299112
Sphenopalatine ganglion blockD059387112
Hiv infectionsD015658EFO_0000764B2022
Parathyroid neoplasmsD01028211
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Congenital hip dislocationD006618HP_0001385Q65.233
Postoperative complicationsD01118333
Renal insufficiencyD051437HP_0000083N1933
EstheticsD00495422
Diabetic footD017719EFO_100145922
HyperparathyroidismD006961EFO_0008506E21.322
Liver neoplasmsD008113EFO_1001513C22.022
ConfusionD003221F44.8922
PancreatitisD010195EFO_0000278K8522
Diabetic neuropathiesD003929EFO_100078322
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEVOCABASTINE
INNlevocabastine
Description
Levocabastine is a member of piperidines.
Classification
Small molecule
Drug classantihistaminics (histamine-H1 receptor antagonists)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H]1CN([C@H]2CC[C@](C#N)(c3ccc(F)cc3)CC2)CC[C@]1(C(=O)O)c1ccccc1
Identifiers
PDB
CAS-ID79516-68-0
RxCUI28627
ChEMBL IDCHEMBL1615438
ChEBI ID
PubChem CID54385
DrugBankDB01106
UNII IDH68BP06S81 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NTSR2
NTSR2
Organism
Homo sapiens
Gene name
NTSR2
Gene synonyms
NCBI Gene ID
Protein name
neurotensin receptor type 2
Protein synonyms
Levocabastine-sensitive neurotensin receptor, neurotensin receptor, type 2, NT-R-2
Uniprot ID
Mouse ortholog
Ntsr2 (18217)
neurotensin receptor type 2 (Q8VIF5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 372 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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398 adverse events reported
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