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Ixabepilone
Ixempra (ixabepilone) is a small molecule pharmaceutical. Ixabepilone was first approved as Ixempra kit on 2007-10-16. It is used to treat breast neoplasms in the USA. The pharmaceutical is active against tubulin beta chain.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Ixempra
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ixabepilone
Tradename
Company
Number
Date
Products
IXEMPRA KITR-PharmN-022065 RX2007-10-16
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ixempraNew Drug Application2020-12-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Ixabepilone, Ixempra Kit, R-Pharm Us Llc
73122372024-08-21U-965
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01D: Cytotoxic antibiotics and related substances
— L01DC: Other cytotoxic antibiotics in atc
— L01DC04: Ixabepilone
HCPCS
Code
Description
J9207
Injection, ixabepilone, 1 mg
Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.01082—117
Myelodysplastic syndromesD009190D46442——9
CholangiocarcinomaD018281C22.12—1——3
Biliary tract neoplasmsD001661C24.9——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GliomaD005910EFO_000052022———4
NeoplasmsD009369C8012———3
ChondrosarcomaD00281311———2
Non-hodgkin lymphomaD008228C85.9—1———1
SarcomaD012509—1———1
NeuroblastomaD009447EFO_0000621—1———1
OsteosarcomaD012516—1———1
MedulloblastomaD008527—1———1
Rhabdoid tumorD018335—1———1
EpendymomaD004806—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—4————4
Hematologic neoplasmsD0193371————1
Hepatic insufficiencyD0485501————1
Pancreatic ductal carcinomaD0214411————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIXABEPILONE
INNixabepilone
Description
Ixabepilone is a macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is a member of 1,3-thiazoles, a beta-hydroxy ketone, a lactam, a macrocycle and an epoxide.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)N1
Identifiers
PDB7DAF
CAS-ID219989-84-1
RxCUI337523
ChEMBL IDCHEMBL1201752
ChEBI ID63605
PubChem CID6445540
DrugBankDB04845
UNII IDK27005NP0A (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
P07437
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,917 documents
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Safety
Black-box Warning
Black-box warning for: Ixempra
Adverse Events
Top Adverse Reactions
Mock data
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1,116 adverse events reported
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