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Iloperidone
Fanapt (iloperidone) is a small molecule pharmaceutical. Iloperidone was first approved as Fanapt on 2009-05-06. It is used to treat schizophrenia and schizophrenia spectrum and other psychotic disorders in the USA. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 6, and D(2) dopamine receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Fanapt (generic drugs available since 2022-05-05)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Iloperidone
Tradename
Company
Number
Date
Products
FANAPTVanda PharmaceuticalsN-022192 RX2009-05-06
7 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
fanaptNew Drug Application2018-09-25
iloperidoneANDA2022-12-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
schizophreniaEFO_0000692D012559F20
schizophrenia spectrum and other psychotic disordersD019967
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Iloperidone, Fanapt, Vanda Pharms Inc
90742542031-12-28U-1674
90742562031-02-10U-1674
90727422031-01-16U-1674
90742552030-12-17U-1674
89996382030-10-28U-1674
86527762030-08-31U-1685
91571212030-04-05U-1674
85866102027-11-02U-1625
91384322025-09-30U-1737
ATC Codes
N: Nervous system drugs
N05: Psycholeptics
N05A: Antipsychotics
N05AX: Other antipsychotics in atc
N05AX14: Iloperidone
HCPCS
No data
Clinical
Clinical Trials
206 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.040631844104
Myelodysplastic syndromesD009190D46111761129
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.02566218
Promyelocytic leukemia acuteD015473C92.421328
Philadelphia chromosomeD010677112
Non-hodgkin lymphomaD008228C85.9112
Large b-cell lymphoma diffuseD016403C83.311
Burkitt lymphomaD002051C83.711
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C9512302054
Monocytic leukemia acuteD007948462111
Myelomonocytic leukemia acuteD015479C92.5451110
Erythroblastic leukemia acuteD004915EFO_1001257C94.0451110
Megakaryoblastic leukemia acuteD007947C94.235119
Myeloid leukemiaD007951C9225117
Liver neoplasmsD008113EFO_1001513C22.014116
AnemiaD000740EFO_0004272D64.913215
LymphomaD008223C85.9415
Myelomonocytic leukemia chronicD015477C93.121114
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340145
Basophilic leukemia acuteD015471C94.8133
Eosinophilic leukemia acuteD015472133
Biphenotypic leukemia acuteD015456C95.0133
Graft vs host diseaseD006086D89.8122
Myeloid sarcomaD023981C92.311
Multiple myelomaD009101C90.011
Myeloproliferative disordersD009196D47.111
B-cell lymphomaD01639311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FibrosisD00535511
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatocellular carcinomaD006528C22.011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameILOPERIDONE
INNiloperidone
Description
Iloperidone is a member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia. It has a role as a serotonergic antagonist, a dopaminergic antagonist and a second generation antipsychotic. It is a monoamine, an organofluorine compound, a tertiary amino compound, a methyl ketone, a member of 1,2-benzoxazoles, a member of piperidines, an aromatic ether and an aromatic ketone.
Classification
Small molecule
Drug classantipsychotics (risperidone type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(C(C)=O)ccc1OCCCN1CCC(c2noc3cc(F)ccc23)CC1
Identifiers
PDB
CAS-ID133454-47-4
RxCUI73178
ChEMBL IDCHEMBL14376
ChEBI ID65173
PubChem CID71360
DrugBankDB04946
UNII IDVPO7KJ050N (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR7
HTR7
HTR1A
HTR1A
HTR6
HTR6
DRD2
DRD2
Organism
Homo sapiens
Gene name
HTR7
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 7
Protein synonyms
5-HT-7, 5-HT-X, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled), Serotonin receptor 7
Uniprot ID
Mouse ortholog
Htr7 (15566)
5-hydroxytryptamine receptor 7 (Q14A50)
Variants
Clinical Variant
No data
Financial
Fanapt - Vanda Pharmaceuticals
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 867 documents
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Safety
Black-box Warning
Black-box warning for: Fanapt, Iloperidone
Adverse Events
Top Adverse Reactions
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5,366 adverse events reported
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